Personalized Medicine in Metabolism Disorders
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: 10 October 2025 | Viewed by 15
Special Issue Editor
Special Issue Information
Dear Colleagues,
Metabolic disorders encompass a diverse range of conditions characterized by disruptions in cellular metabolism, which impact the processing of macronutrients and energy balance. These disorders have reached epidemic levels, with metabolic syndrome affecting approximately 20-25% of the global adult population.
While metabolic diseases often have a genetic predisposition, they may remain dormant until triggered by environmental or lifestyle factors. Since the late 1980s, the prevalence of metabolic syndrome has increased by over 35%, mirroring the rise in obesity, type 2 diabetes mellitus, and cardiovascular diseases. The concept of metabolic syndrome has evolved from early observations made by Kylin in the 1920s to its formal introduction as "Syndrome X" by Reaven in 1988. Organizations such as the World Health Organization (WHO) and the International Diabetes Federation (IDF) have subsequently refined its definition and diagnostic criteria.
Current research aims to clarify metabolic disorders' pathophysiological mechanisms, develop innovative preventive strategies, and enhance treatment modalities. This research involves a multidisciplinary approach, including nutritional interventions, physical activity programs, pharmacological treatments, and genetic profiling.
Recent studies have focused on the complex interactions between genetic predisposition, epigenetic modifications, gut microbiota composition, and lifestyle factors in metabolic health. Emerging areas of investigation include the modulation of adipose tissue function, particularly the activation of brown adipose tissue and the browning of white adipose tissue, as potential therapeutic targets. We welcome original research articles, systematic reviews, and meta-analyses that explore innovative methods for preventing, detecting, and treating metabolic disorders. Particular emphasis will be placed on studies examining personalized medicine strategies, novel biomarkers for early diagnosis, and lifestyle interventions that demonstrate efficacy in improving metabolic outcomes.
Dr. Mehrnaz Abbasi
Guest Editor
Manuscript Submission Information
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Keywords
- metabolic syndrome
- obesity
- insulin resistance
- hypertension
- type 2 diabetes
- energy metabolism
- fatty acid oxida-tion
- gut microbiota
- brown adipose tissue (BAT)
- white adipose tissue (WAT)
- nutritional interventions
- lifestyle modifications
- pharmacological treatments
- phytochemicals
- vitamins and supplements
- public health
- epidemiology of obesity
- preventive strategies
- genetic factors
- metabolic health research
- adipose tissue function
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