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Advances in Diagnosis, Pathophysiology, and Therapy of Brain Injury
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Advances in Diagnosis, Pathophysiology, and Therapy of Brain Injury

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 4029

Special Issue Editor

Dr. Marina Zeldovich

E-Mail Website
Guest Editor
Institute of Psychology, University of Innsbruck, Universitätsstrasse 15, 6020 Innsbruck, Austria
Interests: outcomes after adult and pediatric traumatic brain injury (TBI); psychometrics; translation and linguistic validation of questionnaires; reference values and normative data; methods in TBI (outcome) research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue presents the latest advances in diagnostic methods, developments in pathophysiological understanding, and (novel) therapeutic approaches to improve the treatment and management of brain injury.

It aims to advance brain injury research by highlighting the latest developments in diagnostic methods (e.g., multidimensional outcome assessment, patient- and clinician-reported outcomes), pathophysiological understanding (e.g., biomarker research), and therapeutic approaches (e.g., rehabilitation, inpatient and outpatient therapy). It particularly encourages submissions focusing on research across the age span, methodological considerations, and the development of novel approaches to diagnose and treat brain injury sequelae.

Cutting-edge research includes state-of-the-art diagnostic methods (e.g., multidimensional outcome assessment and advanced imaging); biomarker research; innovative therapeutic interventions (e.g., tailored rehabilitation techniques).

We invite you to submit original research articles, reviews, or systematic reviews.

Dr. Marina Zeldovich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain injury
  • brain injury diagnostics
  • multidimensional outcome assessment
  • therapeutic approaches
  • brain injury rehabilitation

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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28 pages, 1768 KiB  
Article
Reference Values for the German Version of the Quality of Life after Brain Injury in Children and Adolescents (QOLIBRI-KID/ADO) from a General Population Sample
by Leonie Krol, York Hagmayer, Nicole von Steinbuechel, Katrin Cunitz, Anna Buchheim, Inga K. Koerte and Marina Zeldovich
J. Pers. Med. 2024, 14(4), 336; https://doi.org/10.3390/jpm14040336 - 23 Mar 2024
Viewed by 1028
Abstract
Assessment of health-related quality of life (HRQoL) after pediatric traumatic brain injury (TBI) has been limited in children and adolescents due to a lack of disease-specific instruments. To fill this gap, the Quality of Life after Traumatic Brain Injury for Children and Adolescents [...] Read more.
Assessment of health-related quality of life (HRQoL) after pediatric traumatic brain injury (TBI) has been limited in children and adolescents due to a lack of disease-specific instruments. To fill this gap, the Quality of Life after Traumatic Brain Injury for Children and Adolescents (QOLIBRI-KID/ADO) Questionnaire was developed for the German-speaking population. Reference values from a comparable general population are essential for comprehending the impact of TBI on health and well-being. This study examines the validity of the German QOLIBRI-KID/ADO in a general pediatric population in Germany and provides reference values for use in clinical practice. Overall, 1997 children and adolescents aged 8–17 years from the general population and 300 from the TBI population participated in this study. The questionnaire was tested for reliability and validity. A measurement invariance (MI) approach was used to assess the comparability of the HRQoL construct between both samples. Reference values were determined by percentile-based stratification according to factors that significantly influenced HRQoL in regression analyses. The QOLIBRI-KID/ADO demonstrated strong psychometric properties. The HRQoL construct was measured largely equivalently in both samples, and reference values could be provided. The QOLIBRI-KID/ADO was considered reliable and valid for assessing HRQoL in a general German-speaking pediatric population, allowing for clinically meaningful comparisons between general and TBI populations. Full article
(This article belongs to the Special Issue Advances in Diagnosis, Pathophysiology, and Therapy of Brain Injury)
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16 pages, 2361 KiB  
Article
Patterns of Alcohol Use in Hispanic Individuals with TBI over the Ten Years Post-Injury: A Model Systems Study
by Juan Carlos Arango-Lasprilla, Jack D. Watson, Miriam J. Rodríguez, Daniela Ramos-Usuga and Paul B. Perrin
J. Pers. Med. 2024, 14(1), 105; https://doi.org/10.3390/jpm14010105 - 18 Jan 2024
Viewed by 1518
Abstract
The study’s aim was to examine alcohol consumption patterns and predictors of consumption across time among Hispanics with traumatic brain injury (TBI) in the U.S. within ten years post-injury. This longitudinal cohort study included 1342 Hispanic individuals (77.6% males) from the multi-site, longitudinal [...] Read more.
The study’s aim was to examine alcohol consumption patterns and predictors of consumption across time among Hispanics with traumatic brain injury (TBI) in the U.S. within ten years post-injury. This longitudinal cohort study included 1342 Hispanic individuals (77.6% males) from the multi-site, longitudinal TBI Model Systems (TBIMS) database. The main outcome measures were consumption information, demographic, and injury characteristics. Across the full sample, alcohol consumption variables generally demonstrated quadratic movement characterized by an initial increase followed by a plateau or slight decrease over the ten years post-injury. The predictors of higher consumption were being men, single, with a history of excessive alcohol use, with a nonviolent mechanism of injury, shorter duration of PTA, and higher levels of education. Participants had a greater number of 5+ drinks/episode occurrences in the past month if they were men and had had a greater number of 5+ drinks/episode occurrences in the month before injury. There was no differential change in alcohol consumption over time as a function of these predictors. This study identified a profile of at-risk Hispanics with TBI for increased alcohol consumption. These individuals should be identified and targeted for early evidence-based alcohol intervention after TBI when results might be most favorable. Full article
(This article belongs to the Special Issue Advances in Diagnosis, Pathophysiology, and Therapy of Brain Injury)
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Review

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18 pages, 2584 KiB  
Review
Value-Based Health Care Implementation: The Case Study of mTBI Biomarkers
by Martina Zibetti, Chiara Di Resta, Giuseppe Banfi and Rossella Tomaiuolo
J. Pers. Med. 2024, 14(6), 634; https://doi.org/10.3390/jpm14060634 - 14 Jun 2024
Viewed by 909
Abstract
Traumatic brain injury is a significant global health issue, affecting approximately 69 million people annually. Early diagnosis is crucial for effective management, and biomarkers provide a promising approach to identifying traumatic brain injury in various settings. This study investigates the perceived usefulness of [...] Read more.
Traumatic brain injury is a significant global health issue, affecting approximately 69 million people annually. Early diagnosis is crucial for effective management, and biomarkers provide a promising approach to identifying traumatic brain injury in various settings. This study investigates the perceived usefulness of biomarker testing in two distinct contexts: emergency departments and sports settings. Comprehensive interviews were conducted among healthcare professionals in emergency departments and sports-related medical staff. The interviews assessed their perceptions of the diagnostic accuracy, practicality, and overall value of traumatic brain injury biomarker testing. The findings indicate that the perceived usefulness of biomarker testing is high among professionals in both settings. However, significant differences emerged in the perceived barriers to implementation, with emergency department staff citing logistical issues and sports professionals expressing cost concerns. Addressing identified barriers could enhance the adoption and effectiveness of these tests, ultimately improving patient outcomes. Future research should focus on optimizing testing protocols and reducing implementation challenges. This study aims to evaluate the implementation of mild traumatic brain injury biomarkers within the framework of value-based health care, focusing on diagnostic accuracy and patient outcomes. Full article
(This article belongs to the Special Issue Advances in Diagnosis, Pathophysiology, and Therapy of Brain Injury)
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