Exploiting Metabolic Weaknesses: A Novel Approach to Overcome Drug Resistance in Cancer Therapy
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".
Deadline for manuscript submissions: 25 January 2025 | Viewed by 173
Special Issue Editor
2. Department of Surgery, Cardiothoracic Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA
Interests: tumor metabolism; immunometabolism; drug resistance; lung cancer; reactive oxygen species (ROS)
Special Issue Information
Dear Colleagues,
Cancer cells are known to rewire their metabolic pathways to rely heavily on glycolysis, a process that promotes their growth, survival, and proliferation. This seminal observation, made over 100 years ago by Otto Warburg, is recognized as the first significant metabolic shift in cancer cell survival. However, evidence suggests that cancer cells undergo further metabolic reprogramming when they develop resistance. This reprogramming shifts their reliance towards oxidative metabolism (OXMET) and relies on other carbon skeleton sources, such as glutamine, to survive. By utilizing amino acids instead of glucose, tumor cells reduce their proliferation rate, which helps them evade the effects of chemotherapies targeting rapidly dividing cells. Moreover, cellular metabolism also plays a crucial role in diminishing the immune cell's ability to inhibit tumor growth. Immune cells face a metabolic disadvantage due to a lack of carbon nutrients, which results from competition with tumor cells in the tumor microenvironment (TME).
By understanding how cellular metabolism influences cancer cells, we aim to identify strategies to circumvent resistance and improve cancer treatment. This Special Issue of the Journal of Personalized Medicine aims to highlight the latest studies in the field of tumor metabolism as well as tumor immunometabolism. Topics of interest include novel insights into metabolomics, metabolites, metabolic pathways/immune functions, inflammation/metabolism, and therapeutic implications.
Dr. Medhi Wangpaichitr
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug resistance
- tumor metabolism
- immunometabolism
- metabolomics
- metabolites
- precision medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
