Prospectives in Regenerative Medicine and Surgery: Stem Cells and Beyond

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Regenerative Medicine and Therapeutics".

Deadline for manuscript submissions: 10 June 2025 | Viewed by 1421

Special Issue Editors


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Guest Editor
Division of Plastic and Reconstructive Surgery, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90133 Palermo, Italy
Interests: reconstructive microsurgery; limb and nerve surgery; nerve regeneration; regenerative medicine; surgical oncology
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Guest Editor
Plastic and Reconstructive Surgery, Department of Surgical Sciences, University of Rome Tor Vergata, 00133 Roma, Italy
Interests: regenerative surgery; stem cells; tissue engineering; regenerative medicine; adipose-derived stem cells; mesenchymal stem cells; MSC-based cancer therapies; breast reconstructive surgery

Special Issue Information

Dear Colleagues,

This comprehensive Special Issue will delve into the diverse facets of regenerative medicine, focusing on advancements in stem cell research and related technologies. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  1. Adipose-Derived Stem Cells (ASCs) and Mesenchymal Stem Cells (MSCs): Novel applications, therapeutic potentials and challenges in utilizing ASCs and MSCs in regenerative medicine.
  2. Tissue Engineering and Scaffolds: Cutting-edge developments in tissue engineering, including the design and application of biomimetic scaffolds for regenerative purposes.
  3. Biomaterials: Advancements in biomaterials and their role in facilitating tissue regeneration and repair.
  4. Organs on a Chip: Progress in the development and utilization of microphysiological systems for studying organ-level responses and interactions.
  5. Three-Dimensional Organoids: Applications, challenges and future directions in the development and use of 3D organoids for regenerative medicine.
  6. Extracellular Vesicles (EVs) and Microvesicles (MVs): Emerging insights into the therapeutic potential and mechanisms of action of EVs and MVs in regenerative medicine.
  7. Clinical Trials and Translational Research: Insights from ongoing clinical trials and translational research in regenerative medicine.
  8. Ethical and Regulatory Considerations: Discussions on ethical dilemmas and regulatory frameworks associated with regenerative medicine.
  9. Emerging Technologies: Exploration of cutting-edge technologies influencing the future of regenerative medicine.
  10. Precision Medicine Approaches in Regenerative Medicine and Surgery: Tailoring regenerative therapies based on individual patient characteristics.

Prof. Dr. Francesca Toia
Dr. Gabriele Storti
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • regenerative surgery
  • adipose-derived stem cells (ASCs)
  • mesenchymal stem cells (MSCs)
  • tissue engineering
  • extracellular vesicles (EVs)
  • microvesicles (MVs)

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Published Papers (1 paper)

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Research

13 pages, 8455 KiB  
Article
Starvation and Inflammation Modulate Adipose Mesenchymal Stromal Cells’ Molecular Signature
by Simona Piccolo, Giulio Grieco, Caterina Visconte, Paola De Luca, Michela Taiana, Luigi Zagra, Enrico Ragni and Laura de Girolamo
J. Pers. Med. 2024, 14(8), 847; https://doi.org/10.3390/jpm14080847 - 9 Aug 2024
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Abstract
Mesenchymal stromal cells (MSCs) and their released factors (secretome) are intriguing options for regenerative medicine approaches based on the management of inflammation and tissue restoration, as in joint disorders like osteoarthritis (OA). Production strategy may modulate cells and secretome fingerprints, and for the [...] Read more.
Mesenchymal stromal cells (MSCs) and their released factors (secretome) are intriguing options for regenerative medicine approaches based on the management of inflammation and tissue restoration, as in joint disorders like osteoarthritis (OA). Production strategy may modulate cells and secretome fingerprints, and for the latter, the effect of serum removal by starvation used in clinical-grade protocols has been underestimated. In this work, the effect of starvation on the molecular profile of interleukin 1 beta (IL1β)-primed adipose-derived MSCs (ASCs) was tested by assessing the expression level of 84 genes related to secreted factors and 84 genes involved in defining stemness potential. After validation at the protein level, the effect of starvation modulation in the secretomes was tested in a model of OA chondrocytes. IL1β priming in vitro led to an increase in inflammatory mediators’ release and reduced anti-inflammatory potential on chondrocytes, features reversed by subsequent starvation. Therefore, when applying serum removal-based clinical-grade protocols for ASCs’ secretome production, the effects of starvation must be carefully considered and investigated. Full article
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