Bioactive Specialized Metabolites from Marine Plants

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 15 February 2025 | Viewed by 3409

Special Issue Editor

Special Issue Information

Dear Colleagues,

Bioactive natural products remain an important and active area of research in the drug discovery field. This Special Issue of Marine Drugs invites contributions to studying organisms derived from marine plants with respect to bioactive specialized metabolites. The issue will focus on highlighting new isolation and structural elucidation approaches, developments in drug discovery, synthesis and medicinal chemistry, structural methods, chemical biology and biotechnology, genomic tools, metabolomics, and bioassay-guided as well as chemical profiling methodologies in relation to the expeditated discoveries and advancement of potential therapeutics. This Special Issue invites reviews and original contributions in any of these areas.

I look forward to receiving your contributions.

Prof. Dr. Sylvia Urban
Guest Editor

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Keywords

  • marine plants
  • algae
  • seaweeds
  • bioactive
  • drug discovery
  • specialized metabolites
  • isolation

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Published Papers (2 papers)

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Research

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13 pages, 1427 KiB  
Article
Structural Elucidation and Antiviral Properties of Pannosides from the Halophyte Aster tripolium L.
by Jaeyoun Lee, Jae-Hyoung Song, Seo-Hyeon Mun, Hyun-Jeong Ko, Soohyun Um and Seung Hyun Kim
Mar. Drugs 2024, 22(12), 524; https://doi.org/10.3390/md22120524 - 21 Nov 2024
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Abstract
Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (14), were isolated from the halophyte Aster tripolium L. (Tripolium pannonicum), and their chemical structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry. Comprehensive structural analysis [...] Read more.
Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (14), were isolated from the halophyte Aster tripolium L. (Tripolium pannonicum), and their chemical structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry. Comprehensive structural analysis revealed the presence of distinct aglycone and glycosidic moieties, along with complex acylation patterns. The acyl chains of pannosides, 3-hydroxybutyrate (3-HB) residues, were derivatized with (S)- and (R)- phenylglycine methyl ester to resolve the absolute configurations of the chiral centers in 3-HB. Then, the acyl chain-containing saponins, pannosides were evaluated for their antiviral activities against enterovirus A71 (EV71), coxsackievirus B3 (CVB3), and rhinovirus 1B (HRV1B). Pannosides exhibited antiviral activities against HRV1B, EV71, and CVB3. These findings suggest that saponins from A. tripolium exhibit potential antiviral activities and could be further explored for their therapeutic applications. Full article
(This article belongs to the Special Issue Bioactive Specialized Metabolites from Marine Plants)
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Review

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28 pages, 2553 KiB  
Review
Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds
by Maria Carpena, Cláudia S. G. P. Pereira, Aurora Silva, Paula Barciela, A. Olivia S. Jorge, Ana Perez-Vazquez, Antia G. Pereira, João C. M. Barreira, M. Beatriz P. P. Oliveira and Miguel A. Prieto
Mar. Drugs 2024, 22(10), 478; https://doi.org/10.3390/md22100478 - 19 Oct 2024
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Abstract
Macroalgae are known as abundant sources of phytochemicals, which offer a plethora of beneficial biological properties. Besides being the most notable classes of compounds found in macroalgae, phlorotannins, bromophenols, and terpenoids comprise some of the most relevant for their biological properties. Phlorotannins, mainly [...] Read more.
Macroalgae are known as abundant sources of phytochemicals, which offer a plethora of beneficial biological properties. Besides being the most notable classes of compounds found in macroalgae, phlorotannins, bromophenols, and terpenoids comprise some of the most relevant for their biological properties. Phlorotannins, mainly prevalent in brown algae and structurally characterized as complex polyphenolic compounds derived from phloroglucinol units, possess robust antioxidant, anti-inflammatory, antitumor, and cytotoxic activities, modulated by factors such as the degree of polymerization and environmental conditions. Bromophenols, halogenated compounds found in algae and other marine organisms, exhibit significant antioxidant and antiviral properties. Their diverse structures and bromination patterns contribute to their potential as therapeutic and chemical defense agents. Pigments (chemically described as primary terpenoids) play a critical role in light absorption and energy transfer in macroalgae and are divided into three main groups: (i) carotenoids, which are primarily found in brown algae and provide photoprotective and antioxidant benefits; (ii) chlorophylls, known for facilitating the conversion of light into biological energy; and (iii) phycobilins, which are mostly found in red algae and play important roles in light absorption and energy transfer, besides providing remarkable health benefits. Finally, secondary terpenoids, which are particularly abundant in red algae (e.g., the Rhodomelaceae family) are central to cellular interactions and exhibit significant antioxidant, antimicrobial, antidiabetic, and anti-inflammatory properties. This study represents a detailed analysis of the biosynthesis, structural diversity, and biological activities of these macroalgae metabolites, emphasizing their potential biological properties. Full article
(This article belongs to the Special Issue Bioactive Specialized Metabolites from Marine Plants)
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