Marine Polysaccharide-Based Biomaterials

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Biomaterials of Marine Origin".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1880

Special Issue Editor

Department of Biology, College of Science, Shantou University, Shantou, China
Interests: polymer materials; polysaccharides polymers; hydrogels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the increasing awareness of environmental protection, the demand for renewable resources is also increasing. Polysaccharides as a kind of renewable, easy to degrade, non-toxic new biological material have gradually received extensive attention. Polysaccharides are characterized by their unique biocompatibility, good biodegradability, low toxicity, and bioactivity. They have been widely used in the biomaterials field. Polysaccharide-based biomaterials will be discussed in this Special Issue.

Polysaccharide-based biomaterial is a new kind of biological functional material with wide applications. Its preparation and application have been widely studied, as polysaccharide-based biomaterials have become a hot spot in current biotechnology research. In this Special Issue, the research progress of polysaccharide-based biomaterial will be discussed, including the nano-drug carriers, wound dressing hydrogel, 3D cell culture scaffolds, etc.

Prof. Dr. Yang Liu
Guest Editor

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Keywords

  • chitosan
  • alginate
  • agarose
  • nano-drug carrier
  • wound dressing
  • hydrogel

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Published Papers (2 papers)

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Research

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19 pages, 6914 KiB  
Article
Interaction of Liposomes Containing the Carrageenan/Echinochrome Complex with Human HaCaT Keratinocytes In Vitro
by Ekaterina S. Menchinskaya, Vladimir I. Gorbach, Evgeny A. Pislyagin, Tatiana Y. Gorpenchenko, Evgeniya A. Pimenova, Irina V. Guzhova, Dmitry L. Aminin and Irina M. Yermak
Mar. Drugs 2024, 22(12), 561; https://doi.org/10.3390/md22120561 - 16 Dec 2024
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Abstract
Liposomal drug delivery systems are successfully used in various fields of medicine for external and systemic applications. Marine organisms contain biologically active substances that have a unique structure and exhibit a wide range of biological activities. Polysaccharide of red seaweed (carrageenan (CRG)), and [...] Read more.
Liposomal drug delivery systems are successfully used in various fields of medicine for external and systemic applications. Marine organisms contain biologically active substances that have a unique structure and exhibit a wide range of biological activities. Polysaccharide of red seaweed (carrageenan (CRG)), and water-insoluble sea urchin pigment (echinochrome (Ech)) interact with each other and form a stable complex. We included the CRG/Ech complex in liposomes for better permeability into cells. In our research, tetramethylrhodamine isothiocyanate TRITC-labeled CRG was synthesized to study the interaction of the complex encapsulated in liposomes with human epidermal keratinocytes (HaCaTs) widely used to expose the skin to a variety of substances. Using confocal microscopy, we found that liposomes were able to penetrate HaCaT cells with maximum efficiency within 24 h, and pre-incubation of keratinocytes with liposomes resulted in the delivery of the CRG/Ech complex into the cytoplasm. We investigated the anti-inflammatory effects of liposomes, including the lysosomal regulation, increased intracellular ROS levels, and increased NO synthesis in lipopolysaccharide (LPS)- or Escherichia coli (E. coli)-induced inflamed skin cells. Liposomes containing the CRG/Ech complex significantly reduced lysosomal activity by 26% in LPS-treated keratinocytes and decreased ROS levels in cells by 23% after LPS exposure. It was found that liposomes with the complex improved the migration of HaCaT keratinocytes incubated with high-dose LPS by 47%. The results of the work, taking into account the good permeability of liposomes into keratinocytes, as well as the anti-inflammatory effect on cells treated with LPS or E. coli, show the prospects of using liposomes containing the CRG/Ech complex as an anti-inflammatory agent in the fight against skin infections. Full article
(This article belongs to the Special Issue Marine Polysaccharide-Based Biomaterials)
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Review

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28 pages, 3458 KiB  
Review
Ulva Seaweed-Derived Ulvan: A Promising Marine Polysaccharide as a Sustainable Resource for Biomaterial Design
by Rizfi Fariz Pari, Uju Uju, Safrina Dyah Hardiningtyas, Wahyu Ramadhan, Rie Wakabayashi, Masahiro Goto and Noriho Kamiya
Mar. Drugs 2025, 23(2), 56; https://doi.org/10.3390/md23020056 - 24 Jan 2025
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Abstract
Green seaweed is currently underused compared with other major seaweed types. Many scientists have reported applications of the green seaweed Ulva in various fields in recent years, which makes it a candidate for biomass production in industrial biorefineries. Ulva contains a unique polysaccharide [...] Read more.
Green seaweed is currently underused compared with other major seaweed types. Many scientists have reported applications of the green seaweed Ulva in various fields in recent years, which makes it a candidate for biomass production in industrial biorefineries. Ulva contains a unique polysaccharide called ulvan, which is being considered for medicinal and pharmacological applications. Ulvan is a sulfated polysaccharide including rhamnose and glucuronic acid residues, which has a range of bioactivities, including immunomodulatory, antimicrobial, and anticoagulant properties. The biocompatibility of ulvan makes it a versatile candidate for biomaterial design. This review presents an in-depth analysis of the potential applications of ulvan, starting with extraction methods and structural/biological characterization and moving on to biomaterial design. We also highlight the advantages of ulvan over traditional seaweed polysaccharides such as agar, carrageenan, and alginate. Full article
(This article belongs to the Special Issue Marine Polysaccharide-Based Biomaterials)
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