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Marine Drugs
Special Issues
Therapeutic Potential of Marine Algae
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Therapeutic Potential of Marine Algae

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 2695

Special Issue Editors

Prof. Dr. Jianhua Fan

E-Mail Website
Guest Editor
State Key Lab of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
Interests: algae; natural products; bioactive function; bioprocess; genetic engineering
Dr. Xiaohui Li

E-Mail Website
Guest Editor
College of Food Science and Engineering, Ningbo University, Ningbo, China
Interests: fucoxanthin; transcriptional regulation; Phaeodactylum tricornutum
Dr. Yingze Wei

E-Mail
Guest Editor
Pathology Department, Tumor Hospital Affiliated to Nantong University, Nantong, China
Interests: tumor; drugs; resistance; therapeutic method; molecular mechanism

Special Issue Information

Dear colleagues,

As an important part of marine ecosystems, marine algae have rich and unique bioactive compounds. These compounds exhibit pharmacological effects such as anti-inflammatory, antioxidant, and antitumor properties. Their discovery has led to increased applications in medicine, notably in tumor therapy, immune regulation, and so on. With the improvement of biotechnology, metabolomics, and genomics, more and more active compounds are being discovered.

This Special Issue aims to comprehensively present the latest research progress and practical applications of marine algae in the therapeutic field, and invites articles focusing on the pharmacological properties and drug discovery of bioactive compounds derived from marine algae. We particularly welcome the articles that discover active compounds with therapeutic potential by using genomic, proteomic, and metabolomic methods.

Prof. Dr. Jianhua Fan
Dr. Xiaohui Li
Dr. Yingze Wei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine algae
  • therapeutic applications
  • bioactive compounds
  • pharmacological properties
  • drug discovery
  • genomics
  • metabolomics
  • biotechnology
  • natural products
  • pharmaceutical potential

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

18 pages, 4279 KiB  
Article
Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from Dictyota dichotoma: In Silico and In Vitro Approaches
by Fouad Oumassi, Khalid Chebbac, Naouar Ben Ali, Soundouss Kaabi, Zineb Nejjar El Ansari, Amira Metouekel, Azeddin El Barnossi, Abdelfattah El Moussaoui, Mohamed Chebaibi, Loubna Bounab, Ibrahim Mssillou, Abdelaaty Abdelaziz Shahat, Brahim El Bouzdoudi and Mohammed L’bachir El Kbiach
Mar. Drugs 2024, 22(12), 565; https://doi.org/10.3390/md22120565 - 17 Dec 2024
Viewed by 790
Abstract
Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, Dictyota dichotoma (D. dichotoma), through phytochemical characterization using liquid chromatography–mass spectrometry (HPLC-MS), [...] Read more.
Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, Dictyota dichotoma (D. dichotoma), through phytochemical characterization using liquid chromatography–mass spectrometry (HPLC-MS), as well as in vitro and in silico evaluation of its biological activities (antioxidant and antimicrobial). Phytochemical characterization revealed that the ethanolic extract of Dictyota dichotoma (DdEx) is rich in phenolic compounds, with a total of 22 phycocompounds identified. Antioxidant activity, measured by various methods, showed an IC50 of 120 µg/mL for the DPPH assay, an EC50 of 120.53 µg/mL for the FRAP assay, and a total antioxidant power of 685.26 µg AAE/mg according to the phosphomolybdate (TAC) method. Evaluation of antibacterial activity showed a zone of inhibition diameter ranging from 11.93 to 22.58 mm, with the largest zone observed for the Escherichia coli (E. coli) strain. For antifungal activity, inhibition zone diameters ranged from 22.38 to 23.52 mm, with the largest recorded for the Saccharomyces cerevisiae (S. cerevisiae) strain. The in silico study identified tetragalloyl-glucose, apigenin-7-O-glucoside, and pentagalloyl-glucose as the most active compounds against NADPH oxidase, with docking scores of −7.723, −7.424, and −6.402 kcal/mol, respectively. Regarding antibacterial activity, apigenin-7-O-glucoside, pelargonidin-3-O-glucoside, and secoisolariciresinol demonstrated high affinity for E. coli beta-ketoacyl-[acyl carrier protein] synthase, with docking scores of −7.276, −6.811, and −6.594 kcal/mol, respectively. These in vitro and in silico evaluations showed that D. dichotoma extract possesses antioxidant and antimicrobial properties, due to its richness in bioactive compounds identified by HPLC. Full article
(This article belongs to the Special Issue Therapeutic Potential of Marine Algae)
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15 pages, 3342 KiB  
Article
Cognitive-Enhancing Effect of Marine Brown Algae-Derived Phenolics through S100B Inhibition and Antioxidant Activity in the Rat Model of Ischemic Stroke
by Jurairat Khongrum, Pratoomporn Yingthongchai, Suriya Tateing and Pratchaya Kaewkaen
Mar. Drugs 2024, 22(10), 451; https://doi.org/10.3390/md22100451 - 1 Oct 2024
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Abstract
Cognitive impairments are frequently reported after ischemic strokes. Novel and effective treatments are required. This study aimed to develop a functional ingredient obtained from marine algae and to determine the effect of the extract on antioxidative stress, as well as neuroprotective effects, in [...] Read more.
Cognitive impairments are frequently reported after ischemic strokes. Novel and effective treatments are required. This study aimed to develop a functional ingredient obtained from marine algae and to determine the effect of the extract on antioxidative stress, as well as neuroprotective effects, in a rat model of MCAO-induced ischemic stroke. Among the selected marine algal extracts, Sargassum polycystum displayed the highest total phenolic content and antioxidative potential, and was subsequently used to evaluate cognitive function in rat models of ischemic stroke. The S. polycystum extract, administered at doses of 100, 300, and 500 mg/kg BW, significantly improved cognitive function by enhancing cognitive performance in the Morris water maze and novel object recognition tests. Biochemical changes revealed that providing S. polycystum increased the activities of SOD, CAT, and GSH-Px by 52.48%, 50.77%, and 66.20%, respectively, and decreased the concentrations of MDA by 51.58% and S100B by 36.64% compared to the vehicle group. These findings suggest that S. polycystum extract may mitigate cognitive impairment in ischemic stroke by reducing oxidative stress and inhibiting S100B expression, thus highlighting its potential as a functional ingredient for drugs and nutraceuticals aimed at neuroprotection. Full article
(This article belongs to the Special Issue Therapeutic Potential of Marine Algae)
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