“Harmful Algae: Natural Products Research and Medical Application Exploration”―Selected Papers from the 18th International Conference on Harmful Algae (ICHA 2018)

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 November 2018) | Viewed by 5816

Special Issue Editors


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Guest Editor
Laboratoire Phycotoxines, Ifremer, Nantes, France
Interests: marine algal; bacterial and cyanobacterial toxins; mass spectrometric analysis of and biological assays for toxins and related metabolites; ecophysiology of toxin production and biosynthesis; HABs and climate change; reference materials; monitoring and risk evaluation
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Co-Guest Editor
CNRS/ Institut de Neurosciences Paris-Saclay, UMR9197 CEA/ DRF/ Institut Frédéric Joliot/ SIMOPRO/ Université Paris-Saclay Toxines, Récepteurs et Canaux ioniques CEA Saclay, Bât. 152, 91191 Gif sur Yvette, France
Interests: marine natural products

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Co-Guest Editor
Muséum National d'Histoire Naturelle, UMR MNHN-CNRS 7245, 12 rue Buffon, 75231 Paris CEDEX 05, France
Interests: cyanobacteria; cyanotoxins; ecotoxicology; blooms; metabolomics

Special Issue Information

Dear Colleagues,

Aquatic phytoplankton (dinoflagellates, cyanobacteria, and diatoms) accounts for ~50% of oxygen and biomass production on Earth, therefore playing a principal role as a carbon dioxide sink. Phytoplankton lifestyle is characterized by massive proliferation (~100,000–1,000,000 cells L-1) covering large aquatic surface areas. Harmful algal blooms (HABs) are detrimental for aquatic ecosystems and when dominated by toxic species, they seriously affect economic activities (fishing, aquaculture, tourism) and public health. It is estimated however that only ~2% of phytoplankton species are able to produce toxins. Worldwide development of marine and freshwater HABs has significantly increased in the last century due to anthropogenic impacts and global climate change affecting the geographical distribution of toxic species and toxin emergence. The International Conference on Harmful Algae ICHA 2018 will take place in Nantes (France) from 21st to 26th October 2018. According to the motto “From ecosystems to socio-ecosystems” and with 21 themes covering all research areas on HABs, from molecular over cellular and organismal levels to eco-physiological and societal levels, ICHA 2018 aims to contribute to the crosstalk between the international scientific community and political deciders on Global Change, HABs and societal challenges.

This Special Issue in Marine Drugs is suited to receive contributions from several of the topics outlined on the website of the 18th ICHA conference (https://www.icha2018.com/scientific-program/session-topics/35). In particular, all topics describing the analysis, biosynthesis and production of algal and cyanobacterial metabolites and their bio-activity, i.e.,

  • Medical applications of algae, cyanobacteria and their toxins
  • Biotechnology or adding value to toxic and harmful algae
  • Novel detection methods "Omic" technologies: Genomics, transcriptomics, proteomics and metabolomics of HABs
  • Human Toxicology
  • Ciguatera and related benthic HAB organisms and toxins

Dr. Philipp Hess
Dr. Romulo Araoz
Dr. Benjamin Marie
Guest Editors

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Published Papers (1 paper)

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Research

15 pages, 1694 KiB  
Article
MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria
by Chi Ying Gary Ding, Li Mei Pang, Zhao-Xun Liang, Kau Kiat Kelvin Goh, Evgenia Glukhov, William H. Gerwick and Lik Tong Tan
Mar. Drugs 2018, 16(12), 505; https://doi.org/10.3390/md16120505 - 13 Dec 2018
Cited by 15 | Viewed by 5084
Abstract
Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect [...] Read more.
Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins present in four environmental marine cyanobacterial samples collected from intertidal areas in Singapore. Based on 16S-ITS rRNA gene sequences, these filamentous cyanobacterial samples collected from Pulau Hantu were determined as Trichodesmium erythraeum, Oscillatoria sp. PAB-2 and Okeania sp. PNG05-4. Organic extracts were prepared and analyzed on LC-HRMS/MS and Global Natural Product Social Molecular Networking (GNPS) for the presence of aplysiatoxin-related molecules. From the molecular networking, six known compounds, debromoaplysiatoxin (1), anhydrodebromoaplysiatoxin (2), 3-methoxydebromoaplysiatoxin (3), aplysiatoxin (4), oscillatoxin A (5) and 31-noroscillatoxin B (6), as well as potential new analogues, were detected in these samples. In addition, differences and similarities in molecular networking clusters related to the aplysiatoxin molecular family were observed in extracts of Trichodesmium erythraeum collected from two different locations and from different cyanobacterial species found at Pulau Hantu, respectively. Full article
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