Synthesis-Driven Structure Assignment of Marine Natural Products
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (25 April 2021) | Viewed by 7125
Special Issue Editor
Special Issue Information
Dear Colleagues,
Marine natural products serve as an important source of chemical probes for dissecting complex biological phenomena as well as chemotherapeutics against a range of human diseases. Elucidation of the structure of natural products is a prerequisite for accurate discussion on their structure–activity relationship and mode-of-interaction with biomolecules. However, a considerable number of incorrectly assigned marine natural products are reported every year, presumably due to heavy reliance on NMR-based structure analysis. Organic synthesis, when combined with NMR spectroscopy and other analytical methods, is a powerful means for structure determination. Synthesis of appropriately designed model compounds aids the assignment of stereochemically complex natural products, and, undoubtedly, total synthesis plays an indispensable role in the establishment of their full structure.
This Special Issue aims to focus on synthesis-driven structure assignment/determination of marine natural products, including discussions on new aspects of synthetic strategies, NMR data analytics, supportive analytical methods, and innovative prediction methods, e.g., quantum chemical calculations and biosynthetic gene cluster analysis.
Prof. Dr. Haruhiko Fuwa
Guest Editor
Manuscript Submission Information
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Keywords
- structure elucidation
- total synthesis
- partial synthesis
- configurational assignment
- spectroscopic analysis
- NMR chemical shift deviation analysis
- HPLC analysis
- quantum chemical calculations
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