Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances III

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 4098

Special Issue Editor

Special Issue Information

Dear Colleagues,

Marine natural products have extraordinary chemical diversity, biochemical specificity and other molecular properties that make them suitable for consideration as lead structures for drug discovery. In this regard, one of the main problems is the typical low bioavailability, which can complicate both the structural characterization and possible future biological and pharmacological developments. For these reasons, an important step in the study and investigation of bioactive marine metabolites is the development of chemical synthesis and synthetic strategies aimed at the preparation of pure compounds and analogs both for structural confirmation and/or for large-scale preparation. Marine natural products could be a pivotal starting point to pave the way to new classes of biologically active compounds with pharmacological potential.

This Special Issue is the third version on these subjects (the first and second editions are available at https://www.mdpi.com/journal/marinedrugs/special_issues/Synthesis_Inspired and https://www.mdpi.com/journal/marinedrugs/special_issues/Synthesis_Immunomodulatory) and aims to collect original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that can favor applications and/or can solve structural challenges common in the field of natural substances.

Dr. Emiliano Manzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine compounds
  • Immunomodulatory molecules
  • Metabolites
  • Drug discovery
  • Synthesis

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Published Papers (1 paper)

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Review

23 pages, 7760 KiB  
Review
Recent Achievements in Total Synthesis for Integral Structural Revisions of Marine Natural Products
by Min Woo Ha, Jonghoon Kim and Seung-Mann Paek
Mar. Drugs 2022, 20(3), 171; https://doi.org/10.3390/md20030171 - 25 Feb 2022
Cited by 6 | Viewed by 3701
Abstract
A great effort to discover new therapeutic ingredients is often initiated through the discovery of the existence of novel marine natural products. Since substances produced by the marine environment might be structurally more complex and unique than terrestrial natural products, there have been [...] Read more.
A great effort to discover new therapeutic ingredients is often initiated through the discovery of the existence of novel marine natural products. Since substances produced by the marine environment might be structurally more complex and unique than terrestrial natural products, there have been cases of misassignments of their structures despite the availability of modern spectroscopic and computational chemistry techniques. When it comes to refutation to erroneously or tentatively proposed structures empirical preparations through organic chemical synthesis has the greatest contribution along with close and sophiscated inspection of spectroscopic data. Herein, we analyzed the total synthetic studies that have decisively achieved in revelation of errors, ambiguities, or incompleteness of the isolated structures of marine natural products covering the period from 2018 to 2021. Full article
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