Marine-Derived Vaccine Adjuvants
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (17 January 2020) | Viewed by 4124
Special Issue Editor
Interests: structure and function of biological membranes; lipids; phase transitons; marine hydrobionts; bacteria; adaptation; antibiotic resistance; lipid-dependent conformation and functions of proteins; lipochaperoning; vaccines; adjuvant vehicles; recombinant proteins; viruses; nanobiotechnology; immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
An immunological (vaccine) adjuvant is a substance or complex of substances that is added to vaccines to boost immune responses to the target antigens. Modern vaccinology is focused on the development of subunit vaccines containing a protective antigen of the pathogen to minimise the risk of adverse effects. Therefore, subunit vaccines are safer than traditional ones, which comprise killed or attenuated whole pathogens. However, most antigens administered alone possess very weak immunogenicity and are unable to provide protection against pathogens. Adjuvants allow one to overcome this problem by enhancing the immunogenicity of antigens and improving the effectiveness of vaccines. Therefore, adjuvants also provide the increased economic effect of vaccination. There are different types of adjuvants: aluminum-based adjuvants, emulsions, lipid-based (ISCOMATRIX, TI-complexes, and liposomes), and polymeric particles, etc. In spite of a wide arsenal of available adjuvants, only few of them are suitable for medical and veterinary vaccines. Hence, the elaboration of new adjuvants, which are more effective and safer, is an urgent problem of vaccinology. Marine organisms are abundant in biologically active substances. Some of them possess an adjuvant activity (a-galactosylceramide, originally isolated from a marine sponge, marine crustacean chitosan, and saponins, and proteins isolated from marine animals, etc.). The main goal of this Special Issue “Marine-Derived Vaccine Adjuvants” is to summarise the achievements in the field of the search for substances of marine origin and their semi-synthetic derivatives that possess adjuvant activity. Research articles and reviews devoted to mechanisms of actions of such adjuvants are also welcome.
Dr. Nina M. Sanina
Guest Editor
Manuscript Submission Information
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Keywords
- Adjuvants
- Marine organisms
- Tubular immunostimulating complexes
- Lipid-induced immunogenicity of antigens
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