Biosynthesis of Marine Microbial Natural Products

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 3939

Special Issue Editor

Special Issue Information

Dear Colleagues,

The field of biosynthesis of marine microbial natural products is a dynamic and interdisciplinary area of research at the intersection of marine biology, microbiology, organic chemistry, and pharmacology. It explores the intricate processes by which marine microbes, residing in vast and diverse aquatic ecosystems, synthesize a plethora of unique natural products with pharmaceutical potential. This Special Issue will focus on unravelling the biosynthetic pathways and mechanisms underlying these processes, thus contributing to microbial biodiscovery and the identification of new metabolites. By investigating theis phenomenon, we aim to deepen the understanding of the ecological roles, genetic regulation, and enzymatic transformations involved, holding great promise for drug discovery, biotechnology, and environmental conservation. In-depth topical review articles discussing marine metabolites will also be taken into consideration.

Dr. Zeinab Khalil
Guest Editor

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Keywords

  • natural product biodiscovery
  • marine microbes
  • drug discovery
  • ecological roles
  • enzymatic pathways
  • metabolite identification
  • genetic regulation
  • biosynthesis of new metabolites
  • microbial biodiscovery

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Published Papers (2 papers)

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Research

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16 pages, 2867 KiB  
Article
Genomic Analysis of Novel Sulfitobacter Bacterial Strains Isolated from Marine Biofilms
by Han Cui, Shen Fan, Wei Ding and Weipeng Zhang
Mar. Drugs 2024, 22(7), 289; https://doi.org/10.3390/md22070289 - 22 Jun 2024
Cited by 2 | Viewed by 1563
Abstract
Bacteria from the genus Sulfitobacter are distributed across various marine habitats and play a significant role in sulfur cycling. However, the metabolic features of Sulfitobacter inhabiting marine biofilms are still not well understood. Here, complete genomes and paired metatranscriptomes of eight Sulfitobacter strains, [...] Read more.
Bacteria from the genus Sulfitobacter are distributed across various marine habitats and play a significant role in sulfur cycling. However, the metabolic features of Sulfitobacter inhabiting marine biofilms are still not well understood. Here, complete genomes and paired metatranscriptomes of eight Sulfitobacter strains, isolated from biofilms on subtidal stones, have been analyzed to explore their central energy metabolism and potential of secondary metabolite biosynthesis. Based on average nucleotide identity and phylogenetic analysis, the eight strains were classified into six novel species and two novel strains. The reconstruction of the metabolic pathways indicated that all strains had a complete Entner–Doudoroff pathway, pentose phosphate pathway, and diverse pathways for amino acid metabolism, suggesting the presence of an optimized central carbon metabolism. Pangenome analysis further revealed the differences between the gene cluster distribution patterns among the eight strains, suggesting significant functional variation. Moreover, a total of 47 biosynthetic gene clusters were discovered, which were further classified into 37 gene cluster families that showed low similarity with previously documented clusters. Furthermore, metatranscriptomic analysis revealed the expressions of key functional genes involved in the biosynthesis of ribosomal peptides in in situ marine biofilms. Overall, this study sheds new light on the metabolic features, adaptive strategies, and value of genome mining in this group of biofilm-associated Sulfitobacter bacteria. Full article
(This article belongs to the Special Issue Biosynthesis of Marine Microbial Natural Products)
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Review

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28 pages, 1219 KiB  
Review
Engineering Fatty Acid Biosynthesis in Microalgae: Recent Progress and Perspectives
by Yanhui Song, Fangzhong Wang, Lei Chen and Weiwen Zhang
Mar. Drugs 2024, 22(5), 216; https://doi.org/10.3390/md22050216 - 9 May 2024
Cited by 1 | Viewed by 1944
Abstract
Microalgal lipids hold significant potential for the production of biodiesel and dietary supplements. To enhance their cost-effectiveness and commercial competitiveness, it is imperative to improve microalgal lipid productivity. Metabolic engineering that targets the key enzymes of the fatty acid synthesis pathway, along with [...] Read more.
Microalgal lipids hold significant potential for the production of biodiesel and dietary supplements. To enhance their cost-effectiveness and commercial competitiveness, it is imperative to improve microalgal lipid productivity. Metabolic engineering that targets the key enzymes of the fatty acid synthesis pathway, along with transcription factor engineering, are effective strategies for improving lipid productivity in microalgae. This review provides a summary of the advancements made in the past 5 years in engineering the fatty acid biosynthetic pathway in eukaryotic microalgae. Furthermore, this review offers insights into transcriptional regulatory mechanisms and transcription factor engineering aimed at enhancing lipid production in eukaryotic microalgae. Finally, the review discusses the challenges and future perspectives associated with utilizing microalgae for the efficient production of lipids. Full article
(This article belongs to the Special Issue Biosynthesis of Marine Microbial Natural Products)
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