Effects of the Glutamatergic System on Metabolic Alterations
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 405
Special Issue Editors
Interests: depression; anxiety; epilepsy; neuroscience; preclinical studies
Special Issues, Collections and Topics in MDPI journals
Interests: depression; anxiety; epilepsy; neuroscience; preclinical studies
Special Issues, Collections and Topics in MDPI journals
Interests: drug technology; drug development; behavioural studies; pharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Receptors for this amino acid are widely distributed in both neurons and glia in the brain, as well as in the spinal cord. Moreover, glutamate pathways are linked to many other neurotransmitter pathways. Glutamate is known to play an important role in many physiological processes. The undisturbed regulation of glutamate metabolism is crucial for the synthesis and oxidation of amino acids and the proper functioning of the CNS. Accordingly, any dysfunction of this neurotransmitter has significant consequences. On the other hand, manipulation of the glutamatergic system may affect the metabolism of, inter alia, energy and membrane lipids, which may also contribute to the development of various CNS diseases. Disorders associated with abnormalities in the glutamatergic system include neuropsychiatric disorders such as schizophrenia, neurodegenerative diseases such as Alzheimer's disease, substance abuse, pain disorders, and depression.
In our Special Issue entitled “Effects of the Glutamatergic System on Metabolic Alterations”, we would like to bring together experts examining the relationship between the glutaminergic system and metabolic changes, which may contribute to understanding the mechanisms underlying the pathophysiology of various CNS diseases, and thus identifying new targets for substances that may be helpful in their therapy. Authors from various fields are encouraged to submit original scientific articles or reviews related to the effects of the glutamatergic system on metabolic changes.
Dr. Anna Serefko
Dr. Aleksandra Szopa
Dr. Katarzyna Świąder
Guest Editors
Manuscript Submission Information
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Keywords
- glutamate
- metabolic alternation
- central nervous system disorders
- preclinical studies
- clinical studies
- metabolism
- glutamate pathways
- amino acid
- neurotransmitter
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