Metabolic Profiling in Neurometabolisms
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: 15 September 2025 | Viewed by 45
Special Issue Editor
Special Issue Information
Dear Colleagues,
The metabolism within the brain, or neurometabolism, encompasses high-complexity metabolic pathways and networks. The energy demand can vary throughout the brain depending on region, degree of activity, and cell type, and is mainly supplied by glucose. In addition to meeting cellular ATP demands, pathways related to glucose, lipid, and amino acid metabolism provide key metabolites to brain activity, including neurotransmitters and other intercellular communication factors, reducing power for biosynthetic and antioxidant pathways, and other molecules that participate in maintaining brain structural and functional integrity. The field of neurometabolism also involves the central control of the body’s energy homeostasis and feeding behavior, which are importantly regulated by the hypothalamus. Not surprisingly, brain metabolic abnormalities and disorders are associated with a wide range of pathological conditions that affect the developing, adult, and aging brain.
This Special Issue of Metabolites aims to cover a broad range of themes addressing brain energy supply and its regulation; genetic, biological (age, gut microbiota, inflammation, oxidative stress), and environmental (nutrition, lifestyle, stress) factors that modulate neurometabolism; cellular metabolic particularities and how they shape brain functions; the role of glial cells in neurometabolism and neuron–glial metabolic cooperations; subcellular/organellar and biochemical processes that lead to damage or dysfunction of neural cells; neurometabolic imaging; peripheral-to-brain crosstalk and how brain influences systemic metabolism; metabolic interventions focusing on neuroprotection and therapeutic opportunities. Other topics regarding brain metabolic profiles in health and disease are also welcome. This Special Issue is not only intended for preclinical results (in vitro and animal models) but is also open to clinical studies, new methods, and review articles.
Dr. Larissa Daniele Bobermin
Guest Editor
Manuscript Submission Information
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Keywords
- brain
- energy homeostasis
- glial cells
- metabolic disorders
- metabolic profiles
- neurometabolism
- neurons
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