Metabolic Reprogramming in Cancer: New Frontiers for Therapeutic Intervention
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 12
Special Issue Editors
Interests: metabolite signaling; mitochondrial metabolism
Interests: cancer metabolism; LC/MS-based metabolomics; nutrition
Interests: nuclear magnetic resonance; metabolomics; bladder cancer; cardiovascular diseases; metabolism and exercise
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer cells rewire metabolism to support their needs for survival, growth, and proliferation. This metabolic rewiring is now recognized as a hallmark feature of cancer cells and has unveiled promising opportunities for developing novel therapies. Despite this promise, however, the metabolic plasticity and heterogeneity in cancer cells present ongoing challenges. Cancer cells can adapt their metabolic pathways to environmental changes and therapeutic pressures, leading to treatment resistance and disease progression. As such, further exploration and understanding of the underlying mechanisms driving metabolic reprogramming in cancer is necessary.
In this Special Issue, we aim to cover the recent progress in cancer therapy by targeting cancer metabolism. We hope to pave the way for innovative and effective therapeutic strategies by addressing the complexities of metabolic plasticity and heterogeneity in cancer cells. The topics include, but are not limited to, the following:
(i) Molecular mechanisms underlying metabolic adaptability in therapeutic resistance;
(ii) Metabolic heterogeneity in cancer;
(iii) Determination of how tumor microenvironment, such as hypoxia and nutrient availability, influence cancer metabolism;
(iv) Development of novel therapies and combination strategies to improve therapeutic efficacies and clinical outcomes.
We seek original research articles, reviews, and short communications and invite researchers, clinicians, and industry professionals to contribute their insights and findings to advance our understanding of cancer metabolism and its application in clinical practice.
Dr. Songhua Hu
Dr. Yahui Wang
Dr. Daniel Oscar Cicero
Guest Editors
Manuscript Submission Information
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Keywords
- cancer metabolism
- metabolic reprogramming
- metabolic plasticity
- cancer heterogeneity
- therapeutic resistance
- tumor microenvironment
- combination therapies
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