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Micromachines
Special Issues
Recent Advances in Implantable Neural Microsystems
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Recent Advances in Implantable Neural Microsystems

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 13693

Special Issue Editor

Prof. Dr. Yoon-Kyu Song

E-Mail Website
Guest Editor
Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea
Interests: nano and micro electronic; photonic; mechanical devices and their applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last few decades, there has been significant progress made towards our understanding of the mechanisms of brain functions and their role in neurological diseases. Among various neuro-technological tools contributing to this progress, brain–machine interfaces (BMIs) with implantable neural microsystems have played a key role by enabling the stimulation and detection of neural activity at unprecedented spatio-temporal resolution from animals. Moreover, recent human clinical trials have extended the potential applications of implantable neural microsystems to the territory of human health. Through this Special Issue, we would like to establish a forum to discuss the recent developments, remaining challenges, and future directions of implantable neural microsystems for brain–machine interfaces.

We invite research papers, reviews, and shorter communications that focus on the system design, materials, device fabrication, packaging, and characterization of implantable neural microsystems to contribute to this Special Issue. Topics of particular interest include, but are not limited to:

  • Implantable ultra-high-density or 3D multi-electrode arrays (MEAs)
  • Multi-modal neural probes and sensors/stimulators
  • Flexible or deformable neural probes
  • Ultra-low-power systems-on-a-chip (SoCs) for neural sensing and stimulation
  • Ultra-high-density neural sensing/stimulating microsystems
  • Distributed neural sensing/stimulating microdevices
  • Energy delivery/harvesting and neural data transmission strategies
  • Microsystem integration technologies
  • Encapsulation materials and techniques
  • Long-term reliability of implantable microsystems
  • Implantable microsystems for peripheral nerve systems
  • Alternative applications of implantable neural microsystems (e.g., sensory prosthetics)
  • Behavioral study in animals with implantable neural microsystems
  • Preclinical and clinical trials of implantable neural microsystems

Prof. Dr. Yoon-Kyu Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (1 paper)

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Research

13 pages, 3101 KiB  
Article
Current Stimulation of the Midbrain Nucleus in Pigeons for Avian Flight Control
by Jungwoo Jang, Changhoon Baek, Sunhyo Kim, Tae-Kyeong Lee, Gwang-Jin Choi, Shinyong Shim, Seunghyeon Yun, Younginha Jung, Chae-Eun Lee, Seunghyung Ko, Kangmoon Seo, Jong-Mo Seo, Moo-Ho Won, Sung J. Kim and Yoon-Kyu Song
Micromachines 2021, 12(7), 788; https://doi.org/10.3390/mi12070788 - 30 Jun 2021
Cited by 13 | Viewed by 12283
Abstract
A number of research attempts to understand and modulate sensory and motor skills that are beyond the capability of humans have been underway. They have mainly been expounded in rodent models, where numerous reports of controlling movement to reach target locations by brain [...] Read more.
A number of research attempts to understand and modulate sensory and motor skills that are beyond the capability of humans have been underway. They have mainly been expounded in rodent models, where numerous reports of controlling movement to reach target locations by brain stimulation have been achieved. However, in the case of birds, although basic research on movement control has been conducted, the brain nuclei that are triggering these movements have yet to be established. In order to fully control flight navigation in birds, the basic central nervous system involved in flight behavior should be understood comprehensively, and functional maps of the birds’ brains to study the possibility of flight control need to be clarified. Here, we established a stable stereotactic surgery to implant multi-wire electrode arrays and electrically stimulated several nuclei of the pigeon’s brain. A multi-channel electrode array and a wireless stimulation system were implanted in thirteen pigeons. The pigeons’ flight trajectories on electrical stimulation of the cerebral nuclei were monitored and analyzed by a 3D motion tracking program to evaluate the behavioral change, and the exact stimulation site in the brain was confirmed by the postmortem histological examination. Among them, five pigeons were able to induce right and left body turns by stimulating the nuclei of the tractus occipito-mesencephalicus (OM), nucleus taeniae (TN), or nucleus rotundus (RT); the nuclei of tractus septo-mesencephalicus (TSM) or archistriatum ventrale (AV) were stimulated to induce flight aviation for flapping and take-off with five pigeons. Full article
(This article belongs to the Special Issue Recent Advances in Implantable Neural Microsystems)
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