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Micromachines
Special Issues
State-of-the-Art in Optical Trapping and Manipulation
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State-of-the-Art in Optical Trapping and Manipulation

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "A：Physics".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 12466

Special Issue Editors

Prof. Dr. Philip Jones

E-Mail Website
Guest Editor
Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK
Interests: optical tweezers; optical binding; singular optics; biophysics
Special Issues, Collections and Topics in MDPI journals
Dr. Guido Bolognesi

E-Mail Website
Guest Editor
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK
Interests: optical tweezers; microfluidics; interfacial transport phenomena; synthetic biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the previous Special Issues of Micromachines, “Optical Trapping and Manipulation” Volume 1 (2019) and Volume 2 (2021), we are pleased to announce the continuation of the Special Issue series with Volume 3 to be titled “State-of-the-Art in Optical Trapping and Manipulation”, and scheduled for publication in 2022–2023.

The Special Issue welcomes contributions on all aspects of optical trapping and manipulation. These may comprise both theoretical and experimental studies, and applications of optical manipulation methods in fields including (but not limited to) single-molecule biophysics, cell biology, microrheology, colloidal interactions, nanotechnology, atmospheric chemistry, and fundamental optics are particularly welcome to showcase the breadth of the current research.

The Special Issue will accept all forms of contributions, including research papers, communications, methods, and review articles that represent the current state of the art in optical trapping.

Prof. Dr. Philip Jones
Dr. Guido Bolognesi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical tweezers
  • optical trapping
  • plasmonics
  • nanoscience
  • biology

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Published Papers (5 papers)

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Research

16 pages, 3086 KiB  
Article
Ray Optics Model for Optical Trapping of Biconcave Red Blood Cells
by Riccardo Tognato and Philip H. Jones
Micromachines 2023, 14(1), 83; https://doi.org/10.3390/mi14010083 - 29 Dec 2022
Cited by 3 | Viewed by 1909
Abstract
Red blood cells (RBCs) or erythrocytes are essential for oxygenating the peripherical tissue in the human body. Impairment of their physical properties may lead to severe diseases. Optical tweezers have in experiments been shown to be a powerful tool for assessing the biochemical [...] Read more.
Red blood cells (RBCs) or erythrocytes are essential for oxygenating the peripherical tissue in the human body. Impairment of their physical properties may lead to severe diseases. Optical tweezers have in experiments been shown to be a powerful tool for assessing the biochemical and biophysical properties of RBCs. Despite this success there has been little theoretical work investigating of the stability of erythrocytes in optical tweezers. In this paper we report a numerical study of the trapping of RBCs in the healthy, native biconcave disk conformation in optical tweezers using the ray optics approximation. We study trapping using both single- and dual-beam optical tweezers and show that the complex biconcave shape of the RBC is a significant factor in determining the optical forces and torques on the cell, and ultimately the equilibrium configuration of the RBC within the trap. We also numerically demonstrate how the addition of a third or even fourth trapping laser beam can be used to control the cell orientation in the optical trap. The present investigation sheds light on the trapping mechanism of healthy erythrocytes and can be exploited by experimentalist to envisage new experiments. Full article
(This article belongs to the Special Issue State-of-the-Art in Optical Trapping and Manipulation)
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10 pages, 1764 KiB  
Article
Dual-Arm Visuo-Haptic Optical Tweezers for Bimanual Cooperative Micromanipulation of Nonspherical Objects
by Yoshio Tanaka and Ken’ichi Fujimoto
Micromachines 2022, 13(11), 1830; https://doi.org/10.3390/mi13111830 - 26 Oct 2022
Cited by 3 | Viewed by 2119
Abstract
Cooperative manipulation through dual-arm robots is widely implemented to perform precise and dexterous tasks to ensure automation; however, the implementation of cooperative micromanipulation through dual-arm optical tweezers is relatively rare in biomedical laboratories. To enable the bimanual and dexterous cooperative handling of a [...] Read more.
Cooperative manipulation through dual-arm robots is widely implemented to perform precise and dexterous tasks to ensure automation; however, the implementation of cooperative micromanipulation through dual-arm optical tweezers is relatively rare in biomedical laboratories. To enable the bimanual and dexterous cooperative handling of a nonspherical object in microscopic workspaces, we present a dual-arm visuo-haptic optical tweezer system with two trapped microspheres, which are commercially available end-effectors, to realize indirect micromanipulation. By combining the precise correction technique of distortions in scanning optical tweezers and computer vision techniques, our dual-arm system allows a user to perceive the real contact forces during the cooperative manipulation of an object. The system enhances the dexterity of bimanual micromanipulation by employing the real-time representation of the forces and their directions. As a proof of concept, we demonstrate the cooperative indirect micromanipulation of single nonspherical objects, specifically, a glass fragment and a large diatom. Moreover, the precise correction method of the scanning optical tweezers is described. The unique capabilities offered by the proposed dual-arm visuo-haptic system can facilitate research on biomedical materials and single-cells under an optical microscope. Full article
(This article belongs to the Special Issue State-of-the-Art in Optical Trapping and Manipulation)
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10 pages, 1685 KiB  
Article
Controllable Formation and Real-Time Characterization of Single Microdroplets Using Optical Tweezers
by Shuai Li, Hanlin Zhang, Wenqiang Li, Yizhou Zhang, Xiaowen Gao, Haiqing Liu, Nan Li and Huizhu Hu
Micromachines 2022, 13(10), 1693; https://doi.org/10.3390/mi13101693 - 8 Oct 2022
Viewed by 1702
Abstract
Existing preparation methods for microdroplets usually require offline measurements to characterize single microdroplets. Here, we report an optical method used to facilitate the controllable formation and real-time characterization of single microdroplets. The optical tweezer technique was used to capture and form a microdroplet [...] Read more.
Existing preparation methods for microdroplets usually require offline measurements to characterize single microdroplets. Here, we report an optical method used to facilitate the controllable formation and real-time characterization of single microdroplets. The optical tweezer technique was used to capture and form a microdroplet at the center of the trap. The controllable growth and real-time characterization of the microdroplet was realized, respectively, by adjusting experimental parameters and by resolving the Raman spectra by fitting Mie scattering to the spike positions of the spectra during the controllable growth of microdroplets. The proposed method can be potentially applied in optical microlenses and virus detection. Full article
(This article belongs to the Special Issue State-of-the-Art in Optical Trapping and Manipulation)
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10 pages, 2906 KiB  
Article
Analysis and Suppression of Laser Intensity Fluctuation in a Dual-Beam Optical Levitation System
by Xia Wang, Qi Zhu, Mengzhu Hu, Wenqiang Li, Xingfan Chen, Nan Li, Xunmin Zhu and Huizhu Hu
Micromachines 2022, 13(7), 984; https://doi.org/10.3390/mi13070984 - 22 Jun 2022
Viewed by 1975
Abstract
Levitated micro-resonators in vacuums have attracted widespread attention due to their application potential in precision force sensing, acceleration sensing, mass measurement and gravitational wave sensing. The optically levitated microsphere in a counter-propagating dual-beam optical trap has been of particular interest because of its [...] Read more.
Levitated micro-resonators in vacuums have attracted widespread attention due to their application potential in precision force sensing, acceleration sensing, mass measurement and gravitational wave sensing. The optically levitated microsphere in a counter-propagating dual-beam optical trap has been of particular interest because of its large measurement range and flexible manipulation. In this system, laser intensity fluctuation directly influences the trap stability and measurement sensitivity, which makes it a crucial factor in improving trapping performance. In this paper, a time-varying optical force (TVOF) model is established to characterize the influence of laser intensity fluctuation in a dual-beam optical trap. The model describes the relationship between the laser intensity fluctuation, optical force and the dynamic motion of the micro-sized sphere. In addition, an external laser intensity control method is proposed, which achieved a 16.9 dB laser power stability control at the relaxation oscillation frequency. The long-term laser intensity fluctuation was suppressed from 3% to 0.4% in a one-hour period. Experiments showed that the particle’s position detection sensitivity and the stability of the relaxation oscillation could be improved by laser intensity fluctuation suppression. Full article
(This article belongs to the Special Issue State-of-the-Art in Optical Trapping and Manipulation)
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12 pages, 2188 KiB  
Article
Simulation and Experiment of the Trapping Trajectory for Janus Particles in Linearly Polarized Optical Traps
by Xiaoqing Gao, Cong Zhai, Zuzeng Lin, Yulu Chen, Hongbin Li and Chunguang Hu
Micromachines 2022, 13(4), 608; https://doi.org/10.3390/mi13040608 - 13 Apr 2022
Cited by 6 | Viewed by 3052
Abstract
The highly focused laser beam is capable of confining micro-sized particle in its focus. This is widely known as optical trapping. The Janus particle is composed of two hemispheres with different refractive indexes. In a linearly polarized optical trap, the Janus particle tends [...] Read more.
The highly focused laser beam is capable of confining micro-sized particle in its focus. This is widely known as optical trapping. The Janus particle is composed of two hemispheres with different refractive indexes. In a linearly polarized optical trap, the Janus particle tends to align itself to an orientation where the interface of the two hemispheres is parallel to the laser propagation as well as the polarization direction. This enables a controllable approach that rotates the trapped particle with fine accuracy and could be used in partial measurement. However, due to the complexity of the interaction of the optical field and refractive index distribution, the trapping trajectory of the Janus particle in the linearly polarized optical trap is still uncovered. In this paper, we focus on the dynamic trapping process and the steady position and orientation of the Janus particle in the optical trap from both simulation and experimental aspects. The trapping process recorded by a high speed camera coincides with the simulation result calculated using the T-matrix model, which not only reveals the trapping trajectory, but also provides a practical simulation solution for more complicated structures and trapping motions. Full article
(This article belongs to the Special Issue State-of-the-Art in Optical Trapping and Manipulation)
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