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Micromachines
Special Issues
Design and Fabrication of Microfluidic Chips and Microdevices
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Design and Fabrication of Microfluidic Chips and Microdevices

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E：Engineering and Technology".

Deadline for manuscript submissions: closed (20 August 2021) | Viewed by 5084

Special Issue Editor

Prof. Dr. Huaying Chen

E-Mail Website
Guest Editor
School of Mechanical Engineering and Automation, Harbin Institute of Technology (Shenzhen), Shenzhen 518005, China
Interests: microfluidics; cell sorting; single cell analysis; paper microfluidics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As a significant frontier of current analytical science, microfluidic technology, plays critical roles in many fields such as disease detection, analytical chemistry, drug screening, cell biology, material synthesis, etc. In recent years, microfluidics has been fastly developing as an interdisciplinary research field. Because of its unique ability in fluid control, microfluidics can realize functions that are difficult using conventional methods. The birth and sustainable development of microfluidic technology create unlimited possibilities for research at the micro and nanoscale. To this end, many microfluidic technologies and components have been developed to provide alternative solutions to problems that cannot usually be solved by traditional technologies. Thus the design and development of microfluidics establish the application foundation in various fields. This Special Issue aims to establish a platform to showcase the design, modeling, and manufacture of any microfluidic components for various applications. Both research articles and review papers from any backgrounds are welcome.

Dr. Huaying Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidic
  • manufacture
  • modeling
  • design

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Published Papers (2 papers)

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Research

9 pages, 28225 KiB  
Article
How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc
by Yao-Tsung Lin, Chien-Sheng Huang and Shi-Chang Tseng
Micromachines 2021, 12(11), 1335; https://doi.org/10.3390/mi12111335 - 30 Oct 2021
Cited by 3 | Viewed by 1709
Abstract
Biochips play an important role in both medical and food industry safety testing. Moreover, magnetic activated cell sorting is a well-established technology for biochip development. However, biochips need to be manufactured by precision instruments, resulting in the high cost of biochips. Therefore, this [...] Read more.
Biochips play an important role in both medical and food industry safety testing. Moreover, magnetic activated cell sorting is a well-established technology for biochip development. However, biochips need to be manufactured by precision instruments, resulting in the high cost of biochips. Therefore, this study used magnetic-activation and mechanics theories to create a novel disc that could manipulate the microfluidic flow, mixing, reaction, and separation on the runner of the disc. The goal of the research was to apply in the field of biomedical detection systems to reduce the cost of biochips and simplify the operation process. The simulation and experimental investigation showed that the pattern of the reaction chamber was stomach-shaped and the reservoir chamber was rectangular-shaped on the disc. The microfluid could be controlled to flow to the reaction chamber from the buffer and sample chamber when the disc spun at 175~200 rpm within three minutes. This was defined as the first setting mode. The microfluid could then be controlled to flow to the reservoir chamber from the reaction chamber when the disc spun at 225 rpm within five to ten minutes. This was defined as the second setting mode. This verified that the pattern design of the disc was optimized for control of the microfluid flow, mixing, reaction, and separation in the runner of the disc by different setting modes. Full article
(This article belongs to the Special Issue Design and Fabrication of Microfluidic Chips and Microdevices)
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12 pages, 6468 KiB  
Article
Design and Fabrication of a Microfluidic Chip for Particle Size-Exclusion and Enrichment
by Luxia Yang, Tian Ye, Xiufeng Zhao, Taotao Hu and Yanlong Wei
Micromachines 2021, 12(10), 1218; https://doi.org/10.3390/mi12101218 - 6 Oct 2021
Cited by 5 | Viewed by 2615
Abstract
Based on the size of particles, a microfluidic chip integrating micro particles capture, controlled release and counting analysis was designed and fabricated in this paper. The chip is composed of a polydimethylsiloxane (PDMS) cover sheet and a PDMS substrate. The PDMS substrate is [...] Read more.
Based on the size of particles, a microfluidic chip integrating micro particles capture, controlled release and counting analysis was designed and fabricated in this paper. The chip is composed of a polydimethylsiloxane (PDMS) cover sheet and a PDMS substrate. The PDMS substrate is made of a sample inlet, microfluidic channels, a micropillar array, a three-dimensional (3D) focusing channel, and a sample outlet. The chip was fabricated by the multistep SU-8 lithography and PDMS molding method in this study. The micropillar array and channels in the chip can be molded in one step and can be replicated multiple times, which reduces the production cost and increases the practicability of the chip. Using a homemade electromagnetic drive device, the detection function of the chip was tested using a deionized water solution containing 22 μm polyethylene particles. The results showed that under the action of electromagnetic force, the chip enriched polyethylene particles; when the electromagnetic force disappeared, the enriched polyethylene particles were released by injecting buffer solution, and it was looked at as new sample solution. The flow rate of the sample solution and the sheath flow solution (deionized water) was injected into the three-dimensional focusing channel at a flow rate ratio of 1:4, and the polyethylene particles sample solution was focused, which could be used for the counting and analysis of polyethylene particles. The work of this paper can provide a reference for the subsequent detection of circulating tumor cells (CTCs). Full article
(This article belongs to the Special Issue Design and Fabrication of Microfluidic Chips and Microdevices)
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