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Micromachines
Special Issues
Microfluidic Rheometry
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Microfluidic Rheometry

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E：Engineering and Technology".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 11029

Special Issue Editor

Dr. Francesco Del Giudice

E-Mail Website
Guest Editor
System and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK
Interests: rheology; microrheology; microfluidics; particle/cell focusing and separation; microscale flow; polyelectrolytes; graphene oxide

Special Issue Information

Dear Colleagues,

The advent of microfluidics opened significant new routes to explore and characterise the flow of complex liquids, such as polymer solutions and biological fluids. Several microfluidic devices for the measure of rheological properties, including viscosity and longest relaxation time in both shear and extensional flows, have been introduced, somehow challenging the well-established bulk rheological techniques. Moreover, microfluidic devices can offer direct access to the behaviour of single polymer chains subjected to flow, thus providing important insights into the polymer dynamics at large. This Special Issue will highlight microfluidic techniques to measure the rheological properties of complex fluids. Microfluidic devices employed to measure rheological properties that are not generally measurable using conventional rheological techniques are of special interest.

We look forward to your submission.

Best Regards,

Dr. Francesco Del Giudice
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viscosity
  • relaxation time
  • rheology
  • polymer solutions
  • rheometry
  • lab-on-chip
  • biofluids
  • viscometry

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Published Papers (3 papers)

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Research

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21 pages, 6151 KiB  
Article
Assessment of Blood Biophysical Properties Using Pressure Sensing with Micropump and Microfluidic Comparator
by Yang Jun Kang
Micromachines 2022, 13(3), 438; https://doi.org/10.3390/mi13030438 - 13 Mar 2022
Cited by 6 | Viewed by 2592
Abstract
To identify the biophysical properties of blood samples consistently, macroscopic pumps have been used to maintain constant flow rates in a microfluidic comparator. In this study, the bulk-sized and expensive pump is replaced with a cheap and portable micropump. A specific reference fluid [...] Read more.
To identify the biophysical properties of blood samples consistently, macroscopic pumps have been used to maintain constant flow rates in a microfluidic comparator. In this study, the bulk-sized and expensive pump is replaced with a cheap and portable micropump. A specific reference fluid (i.e., glycerin solution [40%]) with a small volume of red blood cell (RBC) (i.e., 1% volume fraction) as fluid tracers is supplied into the microfluidic comparator. An averaged velocity (<Ur>) obtained with micro-particle image velocimetry is converted into the flow rate of reference fluid (Qr) (i.e., Qr = CQ × Ac × <Ur>, Ac: cross-sectional area, CQ = 1.156). Two control variables of the micropump (i.e., frequency: 400 Hz and volt: 150 au) are selected to guarantee a consistent flow rate (i.e., COV < 1%). Simultaneously, the blood sample is supplied into the microfluidic channel under specific flow patterns (i.e., constant, sinusoidal, and periodic on-off fashion). By monitoring the interface in the comparator as well as Qr, three biophysical properties (i.e., viscosity, junction pressure, and pressure-induced work) are obtained using analytical expressions derived with a discrete fluidic circuit model. According to the quantitative comparison results between the present method (i.e., micropump) and the previous method (i.e., syringe pump), the micropump provides consistent results when compared with the syringe pump. Thereafter, representative biophysical properties, including the RBC aggregation, are consistently obtained for specific blood samples prepared with dextran solutions ranging from 0 to 40 mg/mL. In conclusion, the present method could be considered as an effective method for quantifying the physical properties of blood samples, where the reference fluid is supplied with a cheap and portable micropump. Full article
(This article belongs to the Special Issue Microfluidic Rheometry)
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12 pages, 1790 KiB  
Article
A Microfluidic Prototype for High-Frequency, Large Strain Oscillatory Flow Rheometry
by Alfredo Lanzaro and Xue-Feng Yuan
Micromachines 2022, 13(2), 256; https://doi.org/10.3390/mi13020256 - 3 Feb 2022
Viewed by 1963
Abstract
We introduce a “Rheo-chip” prototypical rheometer which is able to characterise model fluids under oscillatory flow at frequencies f up to 80 Hz and nominal strain up to 350, with sample consumption of less than 1 mL, and with minimum inertial effects. Experiments [...] Read more.
We introduce a “Rheo-chip” prototypical rheometer which is able to characterise model fluids under oscillatory flow at frequencies f up to 80 Hz and nominal strain up to 350, with sample consumption of less than 1 mL, and with minimum inertial effects. Experiments carried out with deionized (DI) water demonstrate that the amplitude of the measured pressure drop ΔPM falls below the Newtonian prediction at f≥ 3 Hz. By introducing a simple model which assumes a linear dependence between the back force and the dead volume within the fluid chambers, the frequency response of both ΔPM and of the phase delay could be modeled more efficiently. Such effects need to be taken into account when using this type of technology for characterising the frequency response of non-Newtonian fluids. Full article
(This article belongs to the Special Issue Microfluidic Rheometry)
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Review

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20 pages, 9560 KiB  
Review
A Review of Microfluidic Devices for Rheological Characterisation
by Francesco Del Giudice
Micromachines 2022, 13(2), 167; https://doi.org/10.3390/mi13020167 - 22 Jan 2022
Cited by 23 | Viewed by 5416
Abstract
The rheological characterisation of liquids finds application in several fields ranging from industrial production to the medical practice. Conventional rheometers are the gold standard for the rheological characterisation; however, they are affected by several limitations, including high costs, large volumes required and difficult [...] Read more.
The rheological characterisation of liquids finds application in several fields ranging from industrial production to the medical practice. Conventional rheometers are the gold standard for the rheological characterisation; however, they are affected by several limitations, including high costs, large volumes required and difficult integration to other systems. By contrast, microfluidic devices emerged as inexpensive platforms, requiring a little sample to operate and fashioning a very easy integration into other systems. Such advantages have prompted the development of microfluidic devices to measure rheological properties such as viscosity and longest relaxation time, using a finger-prick of volumes. This review highlights some of the microfluidic platforms introduced so far, describing their advantages and limitations, while also offering some prospective for future works. Full article
(This article belongs to the Special Issue Microfluidic Rheometry)
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