Antimicrobial Properties of Nanoparticles

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1082

Special Issue Editor


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Guest Editor
Laboratory of Nanobiotechnology, Embrapa Genetic Resources and Biotechnology, Brasília 70770-917, DF, Brazil
Interests: nanovesicles; antioxidant activity; nanoparticles; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial resistance remains a pressing concern in public health, necessitating novel strategies for combatting infectious diseases. Nanoparticles, with their unique physicochemical properties, offer promising avenues for addressing microbial infections.

This Special Issue focuses on the potential of nanoparticles as innovative antimicrobial agents. We invite submissions covering nanoparticle synthesis, antimicrobial mechanisms, clinical applications and strategies for combating antimicrobial resistance.

Dr. Luciano Paulino da Silva
Guest Editor

Manuscript Submission Information

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Keywords

  • antimicrobial resistance
  • public health
  • nanoparticles
  • antimicrobial agents
  • new antimicrobials

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Published Papers (1 paper)

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Research

16 pages, 4452 KiB  
Article
Nanoarchitectonics for Advancing Bone Graft Technology: Integration of Silver Nanoparticles Against Bacteria and Fungi
by Leticia Ramos Dantas, Maria Alice Witt, Everdan Carneiro and Felipe Francisco Tuon
Microorganisms 2024, 12(12), 2616; https://doi.org/10.3390/microorganisms12122616 - 17 Dec 2024
Viewed by 675
Abstract
Silver nanoparticles have garnered significant attention for their antimicrobial applications. The aim of this study was to develop and characterize a silver nanoparticle-enhanced bone graft and assess its antimicrobial and antibiofilm activities. Bone granules from bovine cancellous femur were impregnated with silver nanoparticles [...] Read more.
Silver nanoparticles have garnered significant attention for their antimicrobial applications. The aim of this study was to develop and characterize a silver nanoparticle-enhanced bone graft and assess its antimicrobial and antibiofilm activities. Bone granules from bovine cancellous femur were impregnated with silver nanoparticles (50 nm). The antimicrobial and antibiofilm activity was tested against various pathogens, including Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Enterococcus faecalis, Acinetobacter baumannii, and Escherichia coli. Biocompatibility and resorption were evaluated in a mouse calvaria model. All the tested pathogens showed susceptibility to silver nanoparticles, with minimal inhibitory concentrations ranging from 0.25 to 4 mg/L. The silver nanoparticle scaffolds demonstrated a significant reduction in biofilm formation across all microorganisms. The graft exhibited a biocompatibility comparable to that of autologous bone, with reduced resorption rates. Additionally, the presence of nanoparticles did not impact radiolucency, and cytotoxicity remained minimal. Bone grafts impregnated with silver nanoparticles effectively reduce biofilm formation, suggesting their potential as a strategic material for various implant applications. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Nanoparticles)
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