Bacterial Stress Response Mechanisms: Signal Perception, Transduction and Adaptation 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Public Health Microbiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2515

Special Issue Editors


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Laboratoire de Microbiologie Signaux et Microenvironnement, LMSM EA4312, Université de Rouen Normandie, IUT Evreux - 55 rue St Germain, 27000 Evreux, France
Interests: bacterial stress response; adaptation; biofilm and virulence; antimicrobial strategies
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Guest Editor
Normandie Sécurité Sanitaire, Université de Rouen Normandie, IUT Evreux - 55 rue St Germain, 27000 Evreux, France
Interests: Pseudomonas aeruginosa; microbial persistence; microbial molecular biology; microbiology; antimicrobial strategies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our 2021 Special Issue "Bacterial Stress Response Mechanisms: Signal Perception, Transduction and Adaptation".

In their natural habitats, bacteria are exposed to changing and challenging environmental conditions that are perceived as stresses, to which they need to adapt to ensure their survival. Pathogens, in particular, must be able to overcome various host defense mechanisms. To cope with stress, bacteria have evolved intricate systems known as stress response, which sense these changes and rapidly trigger the well-orchestrated reprogramming of the expression of specific genes, leading to the production of effectors and allowing their survival and dissemination under these conditions. Stress response regulation involves several molecular pathways at the levels of transcription, translation, and stability of transcripts and of proteins. A better understanding of these stress response mechanisms may be useful for developing new strategies to fight bacteria which, in some cases, represent a significant threat to life.

This Special Issue aims to showcase our increased understanding of the mechanisms by which bacteria sense and respond to stresses encountered in the host or other environments.

Potential topics include, but are not limited to, the following:

  • Bacterial stress response;
  • Molecular mechanisms involved in bacterial adaptation;
  • Response to antimicrobials, host immune system, hormones, and environmental cues;
  • Response to antimicrobial potentiators;
  • Sigma factors, TCS, sncRNA.

Prof. Dr. Sylvie Chevalier
Prof. Dr. Pierre Cornelis
Guest Editors

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Keywords

  • adaptation
  • signal perception and transduction
  • regulation networks

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Published Papers (1 paper)

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Research

25 pages, 5223 KiB  
Article
The Post-Transcriptional Regulatory Protein CsrA Amplifies Its Targetome through Direct Interactions with Stress-Response Regulatory Hubs: The EvgA and AcnA Cases
by Alejandra Matsuri Rojano-Nisimura, Kobe B. Grismore, Josie S. Ruzek, Jacqueline L. Avila and Lydia M. Contreras
Microorganisms 2024, 12(4), 636; https://doi.org/10.3390/microorganisms12040636 - 22 Mar 2024
Cited by 1 | Viewed by 2093
Abstract
Global rewiring of bacterial gene expressions in response to environmental cues is mediated by regulatory proteins such as the CsrA global regulator from E. coli. Several direct mRNA and sRNA targets of this protein have been identified; however, high-throughput studies suggest an expanded [...] Read more.
Global rewiring of bacterial gene expressions in response to environmental cues is mediated by regulatory proteins such as the CsrA global regulator from E. coli. Several direct mRNA and sRNA targets of this protein have been identified; however, high-throughput studies suggest an expanded RNA targetome for this protein. In this work, we demonstrate that CsrA can extend its network by directly binding and regulating the evgA and acnA transcripts, encoding for regulatory proteins. CsrA represses EvgA and AcnA expression and disrupting the CsrA binding sites of evgA and acnA, results in broader gene expression changes to stress response networks. Specifically, altering CsrA-evgA binding impacts the genes related to acidic stress adaptation, and disrupting the CsrA-acnA interaction affects the genes involved in metal-induced oxidative stress responses. We show that these interactions are biologically relevant, as evidenced by the improved tolerance of evgA and acnA genomic mutants depleted of CsrA binding sites when challenged with acid and metal ions, respectively. We conclude that EvgA and AcnA are intermediate regulatory hubs through which CsrA can expand its regulatory role. The indirect CsrA regulation of gene networks coordinated by EvgA and AcnA likely contributes to optimizing cellular resources to promote exponential growth in the absence of stress. Full article
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