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Microorganisms
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Ocular Microorganisms
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Ocular Microorganisms

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 1301

Special Issue Editors

Dr. Carlos Rocha-de-Lossada

E-Mail Website
Guest Editor
Department of Surgery, University of Seville, Ophthalmology Area, 41009 Seville, Spain
Interests: Cornea; corneal infection; corneal transplant; cataract; presbyopia; refractive surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Davide Borroni

E-Mail Website
Guest Editor
Cornea Research Unit, ADVALIA Vision, 20145 Milan, Italy
Interests: refractive surgery; cataract; corneal transplant
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The ocular surface microbiome is a dynamic and complex ecosystem composed of a variety of microorganisms, including bacteria, viruses, fungi, and, occasionally, protozoa. The ocular surface is continuously exposed to environmental elements, and its microbiome plays a crucial role in maintaining homeostasis and defending against pathogens. However, the composition and balance of the ocular microbiome can be influenced by factors such as health status, aging, contact lens use, medications, infections, and ocular surgeries.

This Special Issue will provide a comprehensive overview of the current state of research on the ocular microbiome. It will feature original research articles, reviews, and case studies that explore the diversity of the ocular surface microbial community, their interactions, and its impact on ocular health. Topics will include the role of the ocular microbiome in various eye diseases, the influence of environmental and lifestyle factors on the microbiome, and the development of new diagnostic and therapeutic approaches based on our understanding of the ocular microbiome

Dr. Carlos Rocha-de-Lossada
Dr. Davide Borroni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular microbioma
  • microbiota
  • infectious keratitis
  • endophtalmitis
  • eye infections

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Published Papers (2 papers)

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13 pages, 3172 KiB  
Article
A Comparative Analysis of the Ocular Microbiome: Insights into Healthy Eyes and Anophthalmic Sockets
by Francisco Zamorano-Martín, Guillermo Chumaceiro, Pablo Navarro-Torres, Davide Borroni, Facundo Urbinati, Ángel Molina, Andreu Paytuví-Gallart and Carlos Rocha-de-Lossada
Microorganisms 2024, 12(11), 2298; https://doi.org/10.3390/microorganisms12112298 - 12 Nov 2024
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Abstract
The purpose of this study is to characterize the ocular surface microbiota of patients with an anophthalmic cavity. An eNAT with 1 mL of Liquid Amies Medium was used to collect samples. Microbial DNA from anophthalmic socket and healthy fellow control eye samples [...] Read more.
The purpose of this study is to characterize the ocular surface microbiota of patients with an anophthalmic cavity. An eNAT with 1 mL of Liquid Amies Medium was used to collect samples. Microbial DNA from anophthalmic socket and healthy fellow control eye samples was isolated and sequenced. Raw reads were analyzed with GAIA (v 2.02). The richness and Shannon alpha diversity metrics, as well as Bray–Curtis beta diversity and Wilcoxon signed-rank test values, were computed with R packages such as phyloseq, mia, or DESeq2 to allow for microbiome analysis. Principal coordinate analysis (PCoA) was performed using the function plotReducedDim from the R package scater. The different taxonomic profiles were described under the concept of eye community state type (ECST). The microbiomes of both eyes from 25 patients with an anophthalmic cavity were analyzed in this study. While the microbial communities of paired eyes from the same patients showed notable dissimilarity, no consistent patterns emerged when comparing healthy eyes to anophthalmic sockets. Alpha diversity values did not significantly differ between healthy eyes and anophthalmic socket samples, though there was considerable variability within each group. Notably, anophthalmic socket samples generally exhibited lower abundances of genera such as Staphylococcus, Enterococcus, Paenibacillus, and Sediminibacterium compared to their healthy counterparts. Microbial variability between healthy eyes and anophthalmic sockets may be due to anatomical differences. Further research is needed to determine whether patients without anophthalmic sockets exhibit similar microbiome patterns in both eyes. Full article
(This article belongs to the Special Issue Ocular Microorganisms)
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5 pages, 8713 KiB  
Case Report
Acute Retinal Necrosis Associated with Epstein–Barr Virus Successfully Treated with Antiviral Treatment: A Case Report
by Heejeong You and Joonhyung Kim
Microorganisms 2024, 12(10), 2065; https://doi.org/10.3390/microorganisms12102065 - 15 Oct 2024
Viewed by 646
Abstract
Epstein–Barr virus (EBV) is a rare cause of acute retinal necrosis (ARN) and is known for its poor prognosis and limited response to conventional antiviral treatment. Herein, we report a case of EBV ARN successfully treated with conventional systemic acyclovir and intravitreal ganciclovir [...] Read more.
Epstein–Barr virus (EBV) is a rare cause of acute retinal necrosis (ARN) and is known for its poor prognosis and limited response to conventional antiviral treatment. Herein, we report a case of EBV ARN successfully treated with conventional systemic acyclovir and intravitreal ganciclovir injection. An 85-year-old man presented with visual disturbance of the right eye from 10 days prior. His visual acuity was 20/200 in the right eye and slit lamp examination showed keratic precipitates, 4+ anterior chamber cells, and 1+ anterior vitreous cells. Fundus examination revealed multiple retinal hemorrhages and yellow-whitish necrotic lesion. The patient was clinically diagnosed with ARN. A few days later, EBV DNA was identified in the aqueous humor and in the serum PCR assay. The patient received 350 mg of intravenous acyclovir three times a day with oral prednisolone, and an intravitreal ganciclovir injection (2 mg per dose) was given five times. Over the course of seven weeks, systemic acyclovir was switched to 1g of per-oral valaciclovir three times a day, and oral steroids were successfully tapered. His visual acuity improved to 20/100, and the previous necrotic lesion was markedly decreased in size. Intravenous acyclovir combined with intravitreal ganciclovir may yield successful treatment outcomes in acute retinal necrosis caused by EBV. Full article
(This article belongs to the Special Issue Ocular Microorganisms)
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