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Journals
Microorganisms
Special Issues
Potential Antimicrobial Synergistic Interactions of Natural Products
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Potential Antimicrobial Synergistic Interactions of Natural Products

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1689

Special Issue Editors

Prof. Dr. Antonio Rosato

E-Mail Website
Guest Editor
Department of Pharmacy-Pharmaceutical Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy
Interests: study of the antimicrobial activity of compounds of natural or synthetic origin or repositioned drugs and their synergies
Dr. Alexia Barbarossa

E-Mail Website
Guest Editor
Department of Pharmacy-Pharmaceutical Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy
Interests: study of the antimicrobial activity of compounds of natural or synthetic origin or repositioned drugs and their synergies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The emergence of antimicrobial resistance (AMR) poses a significant threat to global public health. Addressing this challenge requires innovative approaches, including the exploration of natural compounds and essential oils as potential antimicrobial agents. Moreover, the investigation of the synergistic effects of natural substances, endowed with antimicrobial activity, and antibiotics or non-antibiotic drugs represents a promising avenue for combating AMR. Topics may also include, but are not limited to, the following:

  • In vitro and/or in vivo studies of natural compounds;
  • The evaluation of natural products as potential anti-biofilm agents;
  • The development of new delivery systems for natural products and/or their combination with synthetic compounds.

Prof. Dr. Antonio Rosato
Dr. Alexia Barbarossa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • synergistic effect
  • natural substances

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Published Papers (1 paper)

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Research

13 pages, 6936 KiB  
Article
In Vitro Antimicrobial Synergistic Activity and the Mechanism of the Combination of Naringenin and Amikacin Against Antibiotic-Resistant Escherichia coli
by Lankun Yi, Mingze Cao, Xu Chen, Yubin Bai, Weiwei Wang, Xiaojuan Wei, Yuxiang Shi, Yongying Zhang, Tenghe Ma, Zhen Zhu and Jiyu Zhang
Microorganisms 2024, 12(9), 1871; https://doi.org/10.3390/microorganisms12091871 - 11 Sep 2024
Cited by 1 | Viewed by 1348
Abstract
Bacterial drug resistance is becoming an increasingly serious problem, and the development of antibacterial synergists is urgently needed. Combining existing antibiotics with promising nonantibiotic agents is one strategy that has been shown to be effective at overcoming the widespread emergence of antibiotic-resistant pathogens. [...] Read more.
Bacterial drug resistance is becoming an increasingly serious problem, and the development of antibacterial synergists is urgently needed. Combining existing antibiotics with promising nonantibiotic agents is one strategy that has been shown to be effective at overcoming the widespread emergence of antibiotic-resistant pathogens. In this study, we investigated the antibacterial activities and mechanism of naringenin (NG) combined with amikacin (AMK) against multidrug-resistant Escherichia coli (E. coli). We first measured the fractional inhibitory concentration (FIC) of NG combined with antibiotics via the checkerboard method. The results indicated that the combination of NG and AMK had a synergistic effect on E. coli ATCC 25922 and E. coli C7F3. In addition, this synergistic effect was verified by time-kill assays. Moreover, scanning electron microscopy (SEM) was used to observe cell morphology. The results showed that the cell wall of E. coli was destroyed. Furthermore, we assessed the leakage of alkaline phosphatase (AKP), K+, and protein. The extracellular AKP activity increased after the combinational group of 1/2MIC NG and 1/2MIC AMK, suggesting an impairment in cell wall permeability. An increase in the leakage of intracellular K+ and protein indicated an increase in cell inner membrane permeability. These results revealed that NG and AMK inhibited E. coli by damaging cell walls and membranes. In addition, PI uptake rapidly increased after treatment with NG and AMK. Confocal laser scanning microscopy (CLSM) revealed that NG caused cell wall and cell membrane damage in E. coli. In summary, our results provide a new strategy for responding to the development of E. coli drug resistance. Full article
(This article belongs to the Special Issue Potential Antimicrobial Synergistic Interactions of Natural Products)
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