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Microorganisms
Special Issues
Host versus Pathogen: Candida Infections, Immune Response and Therapy Perspectives
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Host versus Pathogen: Candida Infections, Immune Response and Therapy Perspectives

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 7053

Special Issue Editors

Dr. Eva Pericolini

E-Mail Website
Guest Editor
Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy
Interests: innate immunity to fungal infections; Candida; mucosal candidiasis; microbiota and mycobiota; fungal and bacterial biofilm; antifungal strategies
Special Issues, Collections and Topics in MDPI journals
Dr. Elena Roselletti

E-Mail Website
Guest Editor
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Interests: C. albicans; Candida; candidiasis

Special Issue Information

Dear Colleagues,

Candida spp. can be detected on the mucosal surfaces of around 50–70% of healthy individuals but it can also induce a wide range of cutaneous, mucosal and systemic infections every year under predisposing conditions, such us breaches in intestinal barriers, dysbiosis and immunodeficiency.

Candida albicans is considered the main human fungal pathogen, but recently there has been an increase in infections induced by non-albicans Candida species. One of the species causing the greatest global concern is Candida auris, an emerging multidrug-resistant strain, first described in Japan in 2009, that has recently been included in the group of the critical priority fungal pathogens by the WHO.

The interplay between Candida spp. and the host immune system is fundamental to resolving the infection and, after initial recognition, innate and adaptive immune cells as well as non-immune cells, contribute to the antifungal response.

This Special Issue of Microorganisms aims to provide a collection of articles highlighting recent discoveries and advances in the field of Candida study, from the perspectives of both the host and the pathogen. Studies regarding potential new therapeutic approaches and those on the role of the interactions with other microorganisms during the infection process are also welcome.

As Guest Editors of this Special Issue, we invite you to submit research articles, reviews, and short communications covering a range of Candida infections and the host immune response they elicit.

We look forward to receiving your contributions.

Dr. Eva Pericolini
Dr. Elena Roselletti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Candida spp.
  • candidiasis
  • mucosal infection
  • invasive infection
  • innate immune response
  • adaptive immune response
  • drug resistance
  • anti-Candida therapies

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Published Papers (2 papers)

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Research

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12 pages, 2818 KiB  
Article
Modulation of C. albicans-Induced Immune Response in Vaginal Epithelial Cells by Garcinoic Acid
by Samuele Sabbatini, Linda Zatini, Eleonora Narducci, Lucrezia Rosati, Andrea Ardizzoni, Antonella Mencacci, Mario Rende, Eva Pericolini, Francesco Galli, Desirée Bartolini and Claudia Monari
Microorganisms 2024, 12(12), 2455; https://doi.org/10.3390/microorganisms12122455 - 29 Nov 2024
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Abstract
Vulvovaginal candidiasis (VVC) is a prevalent women’s infection characterized by excessive inflammation and damage of the vaginal epithelium that, in its recurrent form (RVVC), causes more than three symptomatic episodes per year, impacting nearly 8% of women globally. Current antifungal treatments alleviate symptoms [...] Read more.
Vulvovaginal candidiasis (VVC) is a prevalent women’s infection characterized by excessive inflammation and damage of the vaginal epithelium that, in its recurrent form (RVVC), causes more than three symptomatic episodes per year, impacting nearly 8% of women globally. Current antifungal treatments alleviate symptoms but often fail to restore the inflammatory homeostasis of mucosal tissue and prevent recurrences. α-Tocopherol (α-TOH) and garcinoic acid (GA), a vitamin E metabolite, with immunomodulatory properties, were investigated for the first time in vaginal epithelial cells exposed to C. albicans infection to assess their effects on inflammatory signaling parameters important to restore cellular homeostasis. For this purpose, the protein kinases MKK3/6, p38 stress kinase (SAPK), and ERK1/2 were studied together with c-Fos transcription factor and IL-6, IL-1α, and IL-1β secretion in A-431 vaginal epithelial cells pre-treated with GA or with α-TOH and then infected with C. albicans. GA, differently from α-TOH, significantly reduced the C. albicans-induced activation of p38-SAPK while increasing pro-survival MAPK ERK1/2 activity. This resulted in a significant reduction in the secretion levels of the inflammatory cytokines IL-6 and IL-1α, as well as IL-1β. Overall, our data indicate that GA holds potential for restoring the immuno-metabolic properties of the vaginal epithelium exposed to C. albicans infection, which may help to treat inflammatory symptoms in VVC/RVVC. Full article
(This article belongs to the Special Issue Host versus Pathogen: Candida Infections, Immune Response and Therapy Perspectives)
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Review

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16 pages, 2481 KiB  
Review
Candida auris Outbreaks: Current Status and Future Perspectives
by Silvia De Gaetano, Angelina Midiri, Giuseppe Mancuso, Maria Giovanna Avola and Carmelo Biondo
Microorganisms 2024, 12(5), 927; https://doi.org/10.3390/microorganisms12050927 - 1 May 2024
Cited by 5 | Viewed by 6397
Abstract
Candida auris has been identified by the World Health Organization (WHO) as a critical priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream and less commonly in the cerebrospinal fluid and abdomen, with mortality rates that [...] Read more.
Candida auris has been identified by the World Health Organization (WHO) as a critical priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream and less commonly in the cerebrospinal fluid and abdomen, with mortality rates that range between 30% and 72%. However, no large-scale epidemiology studies have been reported until now. The diagnosis of C. auris infections can be challenging, particularly when employing conventional techniques. This can impede the early detection of outbreaks and the implementation of appropriate control measures. The yeast can easily spread between patients and in healthcare settings through contaminated environments or equipment, where it can survive for extended periods. Therefore, it would be desirable to screen patients for C. auris colonisation. This would allow facilities to identify patients with the disease and take appropriate prevention and control measures. It is frequently unsusceptible to drugs, with varying patterns of resistance observed among clades and geographical regions. This review provides updates on C. auris, including epidemiology, clinical characteristics, genomic analysis, evolution, colonisation, infection, identification, resistance profiles, therapeutic options, prevention, and control. Full article
(This article belongs to the Special Issue Host versus Pathogen: Candida Infections, Immune Response and Therapy Perspectives)
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