Gut Dysbiosis in Extraintestinal and Intestinal Diseases: Novel Target for Therapeutic Approaches
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".
Deadline for manuscript submissions: 15 March 2025 | Viewed by 962
Special Issue Editor
Special Issue Information
Dear Colleagues,
The intestinal microbiome maintains a close relationship with the host’s immunity. The gut microbiota interferes in the host’s metabolism, drives the immune response, induces gut hormone production, and reinforces the intestinal barrier. Alterations in the gut microbiota in diseased states are referred to as gut dysbiosis. The concept of gut dysbiosis includes changes in microbiome diversity and/or functional activity with altered bacterial metabolite secretion, particularly short-chain fat acids (SCFAs). Gut microbiota dysbiosis has recently been described in several diseases, including neurological, cardiovascular, metabolic, and autoimmune disorders. Although a causal relationship between gut dysbiosis and diseases remains elusive, recent evidence demonstrates that gut dysbiosis may cause or exacerbate some diseases. Gut dysbiosis might result in the excessive activation of toll-like receptors (TLRs) and a low SCFA production, contributing to the development of extraintestinal or intestinal diseases. It is known that gut dysbiosis is also able to promote molecular mimetism against autoantigens, trigger abnormal immune responses in the gut, favor leaky gut, cause bacterial translocation, and elicit an inflammatory response locally in the gut and other systemic tissues. Novel insights into the modulation of gut microbiota composition, such as prebiotic, probiotic, and postbiotic composition, as a preventive or therapeutic approach have emerged in recent years.
Prof. Dr. Daniela Sartori
Guest Editor
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Keywords
- intestinal microbiome
- gut microbiota
- gut dysbiosis
- host metabolism
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