Advances in African Swine Fever Virus
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2010
Special Issue Editors
Interests: virus; pathogenicity; innate immune; signaling pathway; host–virus interaction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
African swine fever (ASF) is a highly contagious infectious disease caused by African swine fever virus (ASFV). ASFV-infected domestic pigs and wild boars have a mortality rate as high as 100%. Since there is no commercial vaccine available to prevent ASF, it has spread rapidly and caused a great challenge for the swine industry worldwide. ASFV encodes more than 167 proteins that not only execute their functions in virus replication, but also regulate host antiviral immune responses. The ASFV proteins E248R and E199L are involved in membrane fusion, and DP71L, A224L and EP424R regulate viral translation. Some ASFV proteins, such as MGF_505-7R, E120R, DP96R, A137R, I215L and MGF_360-12L, inhibit the innate immune response via different mechanisms. However, the pathogenesis, immune evasion and immune protection mechanism of ASFV are still not fully understood, limiting the development of safe and effective ASF vaccines. Therefore, it is urgent to study the molecular and cellular mechanisms of ASFV escaping innate and adaptive immune responses in the host.
This Special Issue aims to explore the pathogenesis, immune evasion and immune protective mechanism of ASFV and provide theoretical support for the design and development of novel effective ASFV vaccines.
Dr. Li Huang
Dr. Dan Li
Guest Editors
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