Microbial Bioprocesses

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 985

Special Issue Editor


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Guest Editor
Department of Bioprocess Engineering and Biotechnology, Polytechnic Center, Federal University of Parana, Rua Cel. Francisco H. dos Santos—100, Curitiba 81530-000, PR, Brazil
Interests: industrial processes; bioprocesses; biotechnology; bioenergy; fermentative processes

Special Issue Information

Dear Colleagues,

The Special Issue entitled "Microbial Bioprocesses" highlights advances and innovations in the use of microorganisms for biotechnological processes in different areas, such as health, environment, food and energy. With a focus on sustainable processes and the application of emerging technologies, this collection brings together studies on the production of biopharmaceuticals, biopolymers, biofuels, as well as strategies for bioremediation and bioconversion. In addition, it addresses the development of new bioprocesses, genetic engineering of microorganisms and the optimization of fermentation conditions, seeking greater efficiency, cost reduction and minimal environmental impact. The Issue is an important reference for researchers, academics and professionals interested in exploring the potential of microorganisms to solve global challenges and promote the bioeconomy.

Dr. Walter José Martínez-Burgos
Guest Editor

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Keywords

  • microbial biotechnology
  • fermentation
  • biopharmaceuticals
  • biofuels
  • biopolymers
  • bioremediation
  • bioconversion
  • metabolic engineering
  • industrial microorganisms
  • sustainable production
  • bioeconomy
  • bioprocess optimization
  • emerging technologies
  • sustainability

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Published Papers (1 paper)

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Research

19 pages, 2919 KiB  
Article
De Novo Assembly of the Polyhydroxybutyrate (PHB) Producer Azohydromonas lata Strain H1 Genome and Genomic Analysis of PHB Production Machinery
by Daniele Traversa, Carlo Pazzani, Pietro D’Addabbo, Lucia Trisolini, Matteo Chiara, Marta Oliva, Angelo Marzella, Camilla Mandorino, Carla Calia, Guglielmina Chimienti, Caterina Manzari, Graziano Pesole and Maria Scrascia
Microorganisms 2025, 13(1), 137; https://doi.org/10.3390/microorganisms13010137 - 10 Jan 2025
Viewed by 574
Abstract
Polyhydroxybutyrate (PHB) is a biodegradable natural polymer produced by different prokaryotes as a valuable carbon and energy storage compound. Its biosynthesis pathway requires the sole expression of the phaCAB operon, although auxiliary genes play a role in controlling polymer accumulation, degradation, granule formation [...] Read more.
Polyhydroxybutyrate (PHB) is a biodegradable natural polymer produced by different prokaryotes as a valuable carbon and energy storage compound. Its biosynthesis pathway requires the sole expression of the phaCAB operon, although auxiliary genes play a role in controlling polymer accumulation, degradation, granule formation and stabilization. Due to its biodegradability, PHB is currently regarded as a promising alternative to synthetic plastics for industrial/biotechnological applications. Azohydromonas lata strain H1 has been reported to accumulate PHB by using simple, inexpensive carbon sources. Here, we present the first de novo genome assembly of the A. lata strain H1. The genome assembly is over 7.7 Mb in size, including a circular megaplasmid of approximately 456 Kbp. In addition to the phaCAB operon, single genes ascribable to PhaC and PhaA functions and auxiliary genes were also detected. A comparative genomic analysis of the available genomes of the genus Azohydromonas revealed the presence of phaCAB and auxiliary genes in all Azohydromonas species investigated, suggesting that the PHB production is a common feature of the genus. Based on sequence identity, we also suggest A. australica as the closest species to which the phaCAB operon of the strain H1, reported in 1998, is similar. Full article
(This article belongs to the Special Issue Microbial Bioprocesses)
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