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Microorganisms
Special Issues
Resources and Application of Industrial Microorganisms
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Resources and Application of Industrial Microorganisms

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: 14 February 2025 | Viewed by 1461

Special Issue Editor

Prof. Dr. Shoushuai Feng

E-Mail Website
Guest Editor
The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214000, China
Interests: bioprocess; fermentation; bioleaching; extremophiles; physiological and metabolic mechanisms; acidophiles

Special Issue Information

Dear Colleagues,

Industrial microorganisms are the executors in biological manufacturing. The development and application of related resources directly impacts economic benefits. In this Special Issue, high-throughput screening and physicochemical mutagenesis techniques are used to explore industrial microorganism strains, including research on extremophiles and universal studies. The physiological metabolism of industrial microorganisms is studied based on their physiology, genomics, transcriptomics, and proteomics. The impact mechanisms and control strategies of engineering factors such as nutrition, environmental conditions, reactor types, and operational methods on industrial microorganisms are investigated. Based on the product-targeting and chassis-targeting regulatory functions of biological components, the functional characterization, assembly technologies, and chassis microbial systems for universal gene components specifically aimed at certain targets were developed. Heterologous expression systems for industrial microorganisms are constructed to produce enzymes, proteins, and natural products based on bioinformatics analysis. The medication of the host system and the regulation of expression and secretion processes are, respectively, explored. Direct evolution and rational design technologies are also used to enhance the production performance of industrial microorganisms. A non-cellular biosynthesis system for high-value chemical synthesis is established. Aiming at industrial microbial wastewater and waste residue, microbial recycling, repeated fermentation technology, and clean production technology systems were studied.

This Special Issue is dedicated to all aspects of research on the Resources and Application of Industrial Microorganisms, with special emphasis on:

  1. Exploration of industrial microorganism strain resources.
  2. Physiological and omics analysis of industrial microorganism characteristics.
  3. Optimization of industrial microorganism production processes based on fermentation processes.
  4. Improvement of industrial production strains at the molecular level, such as through metabolic engineering and synthetic biology.

Prof. Dr. Shoushuai Feng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • industrial microbial strain resources
  • muti-omics and microbial physiology
  • process optimization
  • metabolic engineering
  • chassis cell

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Published Papers (2 papers)

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Research

13 pages, 1871 KiB  
Article
Genomic and Metabolomic Analyses of Streptomyces albulus with Enhanced ε-Poly-l-lysine Production Through Adaptive Laboratory Evolution
by Xidong Ren, Xinjie Sun, Yan Chen, Xiangheng Xi, Yunzhe Ma, Xinyue Jiang, Xian Zhang, Chenying Wang, Deqiang Zhu and Xinli Liu
Microorganisms 2025, 13(1), 149; https://doi.org/10.3390/microorganisms13010149 - 13 Jan 2025
Viewed by 550
Abstract
ε-poly-l-lysine (ε-PL), a natural food preservative, has garnered widespread attention. It is mainly produced by Streptomyces albulus, but the production by wild-type strains fails to meet the demands of industrialization. To address this issue, adaptive laboratory evolution (ALE) was successfully [...] Read more.
ε-poly-l-lysine (ε-PL), a natural food preservative, has garnered widespread attention. It is mainly produced by Streptomyces albulus, but the production by wild-type strains fails to meet the demands of industrialization. To address this issue, adaptive laboratory evolution (ALE) was successfully employed in this study, subjecting S. albulus CICC 11022 to environmental stresses such as acidic pH and antibiotics (rifampicin, gentamicin, and streptomycin). As a result of ALE, an evolutionary strain S. albulus C214 was obtained, exhibiting an increase in ε-PL production and cell growth by 153.23% and 234.51%, respectively, as compared with the original strain. Genomic and metabolic analyses revealed that mutations occurred in genes responsible for transcriptional regulation, transporter, cell envelope, energy metabolism, and secondary metabolite synthesis, as well as the enrichment of metabolites involved in the biosynthesis of ε-PL. These findings hold great significance for elucidating the mechanism underlying ε-PL synthesis. Full article
(This article belongs to the Special Issue Resources and Application of Industrial Microorganisms)
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16 pages, 8051 KiB  
Article
Synthesis of Super-High-Viscosity Poly-γ-Glutamic Acid by pgdS-Deficient Strain of Bacillus licheniformis and Its Application in Microalgae Harvesting
by Xiaohui Zhang, Wei Wu, Hongxiao Mou, Jun Liu, Lei Lei, Xin Li, Dongbo Cai, Yangyang Zhan, Xin Ma and Shouwen Chen
Microorganisms 2024, 12(12), 2398; https://doi.org/10.3390/microorganisms12122398 - 22 Nov 2024
Viewed by 616
Abstract
Poly-γ-glutamic acid (γ-PGA) is a natural polymer whose molecular weight and viscosity are critical for its application in various fields. However, research on super-high-molecular-weight or -viscosity γ-PGA is limited. In this study, the pgdS gene in Bacillus licheniformis WX-02 was knocked out using [...] Read more.
Poly-γ-glutamic acid (γ-PGA) is a natural polymer whose molecular weight and viscosity are critical for its application in various fields. However, research on super-high-molecular-weight or -viscosity γ-PGA is limited. In this study, the pgdS gene in Bacillus licheniformis WX-02 was knocked out using homologous recombination, and the batch fermentation performances of the recombinant strain WX-ΔpgdS were compared to those of WX-02. Nitrate accumulation was observed in the early fermentation stages of WX-ΔpgdS, and gene transcription analysis and cell morphology observations revealed that nitrite accumulation was caused by oxygen limitation due to cell aggregation. When the aeration and agitation rates were increased to 2.5 vvm and 600 r/min, respectively, and citrate was used as a precursor, nitrite accumulation was alleviated in WX-ΔpgdS fermentation broth, while γ-PGA yield and broth viscosity reached 17.3 g/L and 4988 mPa·s. Scanning electron microscopy (SEM) showed that the γ-PGA produced by WX-ΔpgdS exhibited a three-dimensional porous network structure. At a γ-PGA concentration of 5 mg/L, the fermentation broth of WX-ΔpgdS achieved a flocculation efficiency of 95.7% after 30 min of microalgae settling. These findings demonstrate that pgdS knockout results in super-high-viscosity γ-PGA, positioning it as an eco-friendly and cost-effective biocoagulant for microalgae harvesting. Full article
(This article belongs to the Special Issue Resources and Application of Industrial Microorganisms)
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