Detection and Identification of Emerging and Re-Emerging Pathogens

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 749

Special Issue Editors


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Guest Editor
Hunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410012, China
Interests: virus discovery; viral diversity and evolution; coronavirus; emerging pathogens
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Hunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410012, China
Interests: enterovirus; virus–host interaction; pathogenic mechanism; antiviral
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The frequent emergence and re-emergence of viral epidemics have become a severe threat to public health worldwide. Among these, the prominent emerging pathogen SARS-CoV-2 has had a significant impact in recent years. Concurrently, various pathogens have emerged alongside or followed the COVID-19 epidemic, including both emerging and re-emerging pathogens, such as the mpox virus, dengue virus, adenovirus, enterovirus, and so on. The alternating epidemics and co-epidemics of pathogens, including new strains, mutants, and different serotypes, underscore the importance of enhancing the detection and identification of pathogens. Investigating the discovery, classification, and characterization of pathogens forms the foundation for understanding their prevalence, evolution, transmission, and pathogenicity, thereby providing etiological and epidemiological information for the prevention and control of related diseases.

This Special Issue focuses on the detection and identification of emerging and re-emerging pathogens, encompassing clinical pathogens, zoonotic pathogens, vector-borne pathogens, and more. It aims to enhance our understanding of the genomics, epidemiology, evolution, and pathogenicity of these pathogens, and contribute to their prevention.

Prof. Dr. Xing-Yi Ge
Dr. Ye Qiu
Guest Editors

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Keywords

  • virus
  • pathogen discovery
  • genomic epidemiology
  • intra- and cross-species transmission
  • zoonosis
  • evolution and phylogeny

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Published Papers (1 paper)

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Research

14 pages, 3567 KiB  
Article
Evolutionary Analysis and Antiviral Drug Prediction of Mpox Virus
by Zhong-Hao Lian, Chen-Hui Yang, Ye Qiu and Xing-Yi Ge
Microorganisms 2024, 12(11), 2239; https://doi.org/10.3390/microorganisms12112239 - 5 Nov 2024
Viewed by 650
Abstract
The resurgence of mpox virus (MPXV) poses a significant challenge to global public health. Currently, there is a limited understanding of the evolutionary details of MPXV during its epidemics, and no specific drugs have been developed for it. Herein, analysis of mutations and [...] Read more.
The resurgence of mpox virus (MPXV) poses a significant challenge to global public health. Currently, there is a limited understanding of the evolutionary details of MPXV during its epidemics, and no specific drugs have been developed for it. Herein, analysis of mutations and positive selection sites (PSSs) within the MPXV genomes revealed 799 mutations and 40 PSSs. Visualization analysis indicated that these mutations and PSSs may affect protein structure. Additionally, a protein–protein interaction (PPI) network between human and MPXV was established, identifying 346 MPXV-interacting human proteins (MIHPs). An interaction network involving MIHPs and other viruses confirmed that these proteins can interact with various viruses that infect humans. Functional analysis of MIHPs suggested their enrichment in host immunity pathways. Lastly, two drugs targeting MIHPs and four compounds targeting MPXV proteins were screened as candidate antivirals against MPXV. These findings not only deepen our understanding of MPXV evolution but also aid in the development of anti-MPXV drugs. Full article
(This article belongs to the Special Issue Detection and Identification of Emerging and Re-Emerging Pathogens)
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