Gut Microbiota in Health and Diseases: The Role of Pro-/Pre-/Syn-/Post-Biotics in the Gut–Liver–Brain Axis
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 953
Special Issue Editors
Interests: gut microbiota; metabolic disturbances
Interests: internal medicine; lipidology; gastrointestinal motility, digestion; breath tests; liver steatosis; autoinflammatory disorders; gallstone disease; abdominal ultrasonography; metabolic syndrome
Special Issue Information
Dear Colleagues,
Introduction: The gut microbiome is a diverse array of microorganisms residing in the gastrointestinal tract, forming a complex ecosystem vital for human health. It significantly influences numerous physiological processes, including digestion, metabolism, immune function, and mental health. Notably, the gut–liver–brain axis illustrates the interconnectedness of gut microbiota, metabolic processes, and mental health.
The gut–brain axis and gut metabolic axis are intricately interconnected pathways that illustrate the complex relationship between gut health, brain function, and metabolic processes. The gut–brain axis involves bidirectional communication between the gastrointestinal tract and the central nervous system, which influences mental health. Conversely, the gut–metabolic axis focuses on how gut health impacts metabolic functions, including nutrient absorption and the production of metabolites that regulate metabolism and energy balance. These two axes are linked through various mechanisms, including the influence of gut-derived neurotransmitters on metabolic processes, the impact of stress on gut microbiota composition, and the role of chronic inflammation from gut dysbiosis in affecting both brain function and metabolic health. Understanding these connections underscores the importance of gut health in promoting overall well-being, suggesting that interventions targeting the gut may benefit both mental and metabolic health.
This Special Issue seeks to enhance our understanding of gut–microbiota–brain interaction, essential for creating effective, holistic strategies for prevention and treatment. Investigating how changes in gut microbiota can influence mental and metabolic health outcomes may lead to innovative therapeutic approaches, such as personalized probiotics or dietary adjustments aimed at fostering these issues.
We invite manuscripts that present original research, reviews, and perspectives on all aspects of gut microbiota linked with mental and metabolic health, as well as regarding biotics such as pro-/pre-/syn-/post-biotics in gut–liver–brain axis disorders. Topics of interest include, but are not limited to, the following:
- The impact of gut-derived metabolites on liver function and overall metabolism.
- Probiotic modulation of the gut microbiome as a strategy for mitigating and preventing mental health disorders, as supported by clinical studies.
- The gut–liver–brain axis focuses on how changes in microbiota can alter specific pathways related to gut metabolite production and mental illness.
Dr. Mohamad Khalil
Prof. Dr. Piero Portincasa
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gut microbiome
- gut–liver–brain axis
- gastrointestinal tract
- digestion
- metabolism
- immune function
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