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Microorganisms
Special Issues
Combating Antimicrobial Resistance: Innovations and Strategies
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Combating Antimicrobial Resistance: Innovations and Strategies

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 January 2025 | Viewed by 3390

Special Issue Editor

Dr. Vasiliki Koumaki

E-Mail Website
Guest Editor
Department of Medical Microbiology, Medical School of Athens, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115 27 Athens, Greece
Interests: antimicrobial resistance; multidrug resistant gram-negatives; resistance mechanisms; PK/PD studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) is an escalating global health crisis that threatens the efficacy of antimicrobial agents, including antibiotics, antivirals, antifungals, and antiprotozoals. The misuse and overuse of these drugs in healthcare, agriculture, and animal husbandry have accelerated the development of resistant strains of pathogens.

The battle against AMR requires a multifaceted and coordinated global response. Continued research into understanding resistance mechanisms, the development of new antimicrobial agents, and the implementation of effective stewardship programs are essential to mitigate the growing threat of drug-resistant infections.

In this Special Issue, we encourage research and innovation in diagnostics, vaccines, and new antimicrobial agents to stay ahead of evolving resistance.

Dr. Vasiliki Koumaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial agents
  • antimicrobial resistance
  • antimicrobial stewardship

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Published Papers (2 papers)

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Review

23 pages, 1725 KiB  
Review
Food Webs and Feedbacks: The Untold Ecological Relevance of Antimicrobial Resistance as Seen in Harmful Algal Blooms
by Aabir Banerji, Nichole E. Brinkman, Benjamin Davis, Alison Franklin, Michael Jahne and Scott P. Keely
Microorganisms 2024, 12(11), 2121; https://doi.org/10.3390/microorganisms12112121 - 23 Oct 2024
Viewed by 1294
Abstract
Antimicrobial resistance (AMR) has long been framed as an epidemiological and public health concern. Its impacts on the environment are unclear. Yet, the basis for AMR is altered cell physiology. Just as this affects how microbes interact with antimicrobials, it can also affect [...] Read more.
Antimicrobial resistance (AMR) has long been framed as an epidemiological and public health concern. Its impacts on the environment are unclear. Yet, the basis for AMR is altered cell physiology. Just as this affects how microbes interact with antimicrobials, it can also affect how they interact with their own species, other species, and their non-living environment. Moreover, if the microbes are globally notorious for causing landscape-level environmental issues, then these effects could alter biodiversity and ecosystem function on a grand scale. To investigate these possibilities, we compiled peer-reviewed literature from the past 20 years regarding AMR in toxic freshwater cyanobacterial harmful algal blooms (HABs). We examined it for evidence of AMR affecting HAB frequency, severity, or persistence. Although no study within our scope was explicitly designed to address the question, multiple studies reported AMR-associated changes in HAB-forming cyanobacteria (and co-occurring microbes) that pertained directly to HAB timing, toxicity, and phase, as well as to the dynamics of HAB-afflicted aquatic food webs. These findings highlight the potential for AMR to have far-reaching environmental impacts (including the loss of biodiversity and ecosystem function) and bring into focus the importance of confronting complex interrelated issues such as AMR and HABs in concert, with interdisciplinary tools and perspectives. Full article
(This article belongs to the Special Issue Combating Antimicrobial Resistance: Innovations and Strategies)
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26 pages, 669 KiB  
Review
Antibiotic Resistance in the Elderly: Mechanisms, Risk Factors, and Solutions
by Nikolaos Theodorakis, Georgios Feretzakis, Christos Hitas, Magdalini Kreouzi, Sofia Kalantzi, Aikaterini Spyridaki, Iris Zoe Boufeas, Aikaterini Sakagianni, Evgenia Paxinou, Vassilios S. Verykios and Maria Nikolaou
Microorganisms 2024, 12(10), 1978; https://doi.org/10.3390/microorganisms12101978 - 30 Sep 2024
Cited by 1 | Viewed by 1808
Abstract
Antibiotic resistance presents a critical challenge in healthcare, particularly among the elderly, where multidrug-resistant organisms (MDROs) contribute to increased morbidity, mortality, and healthcare costs. This review focuses on the mechanisms underlying resistance in key bacterial pathogens and highlights how aging-related factors like immunosenescence, [...] Read more.
Antibiotic resistance presents a critical challenge in healthcare, particularly among the elderly, where multidrug-resistant organisms (MDROs) contribute to increased morbidity, mortality, and healthcare costs. This review focuses on the mechanisms underlying resistance in key bacterial pathogens and highlights how aging-related factors like immunosenescence, frailty, and multimorbidity increase the burden of infections from MDROs in this population. Novel strategies to mitigate resistance include the development of next-generation antibiotics like teixobactin and cefiderocol, innovative therapies such as bacteriophage therapy and antivirulence treatments, and the implementation of antimicrobial stewardship programs to optimize antibiotic use. Furthermore, advanced molecular diagnostic techniques, including nucleic acid amplification tests and next-generation sequencing, allow for faster and more precise identification of resistant pathogens. Vaccine development, particularly through innovative approaches like multi-epitope vaccines and nanoparticle-based platforms, holds promise in preventing MDRO infections among the elderly. The role of machine learning (ML) in predicting resistance patterns and aiding in vaccine and antibiotic development is also explored, offering promising solutions for personalized treatment and prevention strategies in the elderly. By integrating cutting-edge diagnostics, therapeutic innovations, and ML-based approaches, this review underscores the importance of multidisciplinary efforts to address the global challenge of antibiotic resistance in aging populations. Full article
(This article belongs to the Special Issue Combating Antimicrobial Resistance: Innovations and Strategies)
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