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Microorganisms
Special Issues
Natural Products for Antimicrobial Therapy
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Natural Products for Antimicrobial Therapy

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 3463

Special Issue Editors

Prof. Dr. Klinger Antonio Da Franca Rodrigues

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Guest Editor
Infectious Disease Laboratory—LADIC, Federal University of Parnaíba Delta—UFDPar, Campus Ministro Reis Velloso, São Benedito, Parnaíba 64202-020, Brazil
Interests: leishmaniasis; chagas disease; immunomodulation; natural products
Special Issues, Collections and Topics in MDPI journals
Dr. Alyne Rodrigues

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Guest Editor
Research Center of Biodiversity and Biotechnology, BIOTEC, Federal University of Delta of Parnaíba, UFDPar, São Sebastião Avenue, Parnaíba 64202-020, PI, Brazil
Interests: natural product; antibacterial

Special Issue Information

Dear Colleagues,

The spectrum of diseases caused by microorganisms affects millions of people around the world. The number of cases of antimicrobial resistance is increasing and represents a threat to the available therapeutic arsenal. Therefore, the search for new antimicrobial agents is a constant concern. Compounds of natural origin are an inexhaustible source of new molecules and have already been employed for the discovery of several antimicrobial agents.

This Special Issue of Microorganisms aims to gather relevant manuscripts involving basic, translational, and clinical research, and covering various advances in treatments for microbial diseases. For this research topic, we are inviting interested researchers to share their original research, relevant findings, and review articles in the areas of antimicrobial drug identification; drug combinations; immunotherapy; drug delivery systems; drug resistance; and target identification–validation for microbial diseases of medical interest.

Prof. Dr. Klinger Antonio Da Franca Rodrigues
Dr. Alyne Rodrigues
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • antimicrobial drug identification
  • drug combinations
  • immunotherapy
  • drug delivery systems
  • drug resistance

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Published Papers (3 papers)

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Research

17 pages, 2605 KiB  
Article
Assessing Normandy Soil Microbial Diversity for Antibacterial Activities Using Traditional Culture and iChip Methods
by Fabien Perrier, Juliette Morice, Sabrina Gueulle, Antoine Géry, Eliette Riboulet-Bisson, David Garon, Cécile Muller and Florie Desriac
Microorganisms 2024, 12(12), 2422; https://doi.org/10.3390/microorganisms12122422 - 25 Nov 2024
Viewed by 715
Abstract
Uncultured microorganisms represent a promising and untapped source of antibacterial compounds, crucial in the fight against the significant threat of antimicrobial resistance (AMR). In this study, both traditional and isolation chip (iChip) cultivation techniques were employed to enhance the recovery of known and [...] Read more.
Uncultured microorganisms represent a promising and untapped source of antibacterial compounds, crucial in the fight against the significant threat of antimicrobial resistance (AMR). In this study, both traditional and isolation chip (iChip) cultivation techniques were employed to enhance the recovery of known and unknown microorganisms from soils located in Normandy, France. The isolates obtained were identified using 16S rDNA or ITS regions analysis and MALDI-TOF mass spectrometry and were screened for antibacterial activity. A total of 386 isolates, belonging to 6 microbial phyla and distributed across 65 genera, were recovered using both methods. In total, 11 isolates are potentially new bacterial species, and 34 were associated with 22 species described recently. The iChip method yielded a higher diversity of microorganisms (47 genera) than the traditional method (38 genera) and was particularly effective in enriching Actinomycetota. Antibacterial screening against target bacteria showed that 85 isolates (22%) exhibited antibacterial activity. The Streptomyces, Pseudomonas, and Bacillaceae taxa accounted for most antibacterial-producing bacteria with some presenting promising undescribed characteristics. Other active isolates were affiliated with less-known antibacterial producers such as Arthrobacter, Chryseobacterium, Delftia, Ensifer, Flavobacterium, Rahnella, and Stenotrophomonas, among others. These results highlight the potential of our microbial collection as a source of new antibacterial natural products. Full article
(This article belongs to the Special Issue Natural Products for Antimicrobial Therapy)
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13 pages, 1875 KiB  
Article
The Extract of Larrea tridentata Promotes the Synthesis of Silver Nanoparticles and Stimulates Immune Responses in Penaeus vannamei Against Vibrio spp., Causing Acute Hepatopancreatic Necrosis Disease
by Germán León-Valdez, Wenceslao Valenzuela-Quiñonez, Píndaro Álvarez-Ruiz, Carlos A. Soto-Robles, Eusebio Nava-Perez, Gabriela López-Cervantes and Magnolia Montoya-Mejía
Microorganisms 2024, 12(11), 2219; https://doi.org/10.3390/microorganisms12112219 - 1 Nov 2024
Viewed by 1092
Abstract
Specific strains of Vibrio parahaemolyticus can cause Acute Hepatopancreatic Necrosis Disease (AHPND), a critical issue in shrimp aquaculture despite the application of several control strategies. The use of antibiotics is now restricted due to increasing bacterial resistance and overuse. Silver nanoparticles (AgNPs) have [...] Read more.
Specific strains of Vibrio parahaemolyticus can cause Acute Hepatopancreatic Necrosis Disease (AHPND), a critical issue in shrimp aquaculture despite the application of several control strategies. The use of antibiotics is now restricted due to increasing bacterial resistance and overuse. Silver nanoparticles (AgNPs) have shown potential in shrimp aquaculture, with applications in boosting immunity against certain types of pathogens, promoting growth, and improving survival rates. However, an economically viable solution that protects the organisms has not been found, which is why the search for nanoparticles synthesized with plant extracts is necessary to generate environmentally friendly control strategies. In this study, we synthesized AgNPs from Larrea tridentata extract and administered them orally with feed over a 35-day period. Shrimps fed with AgNP-enriched diets showed a significant increase (p < 0.05) in mRNA expression of immune-related genes (CTL-5, MNK, SR, and GILT), particularly within the first 24–48 h. No significant differences were observed in growth rates, but survival rates in a challenge against V. parahaemolyticus exceeded 85%, higher than the control group. Based on our findings and previous literature, L. tridentata can effectively promote the synthesis of AgNPs and shows potential as an antimicrobial agent, without affecting the growth or survival of treated shrimp. Full article
(This article belongs to the Special Issue Natural Products for Antimicrobial Therapy)
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16 pages, 3536 KiB  
Article
Anti-Leishmania amazonensis Activity of Morolic Acid, a Pentacyclic Triterpene with Effects on Innate Immune Response during Macrophage Infection
by Vanessa Maria Rodrigues de Souza, Nicolle Barreira Maciel, Yasmim Alves Aires Machado, Julyanne Maria Saraiva de Sousa, Raiza Raianne Luz Rodrigues, Airton Lucas Sousa dos Santos, Maria Gabrielly Gonçalves da Silva, Ingrid Gracielle Martins da Silva, Karine Brenda Barros-Cordeiro, Sônia Nair Báo, Josean Fechine Tavares and Klinger Antonio da Franca Rodrigues
Microorganisms 2024, 12(7), 1392; https://doi.org/10.3390/microorganisms12071392 - 9 Jul 2024
Cited by 1 | Viewed by 1075
Abstract
Leishmaniasis is a group of infectious diseases transmitted to humans during vector bites and caused by protozoans of the genus Leishmania. Conventional therapies face challenges due to their serious side effects, prompting research into new anti-leishmania agents. In this context, we investigated [...] Read more.
Leishmaniasis is a group of infectious diseases transmitted to humans during vector bites and caused by protozoans of the genus Leishmania. Conventional therapies face challenges due to their serious side effects, prompting research into new anti-leishmania agents. In this context, we investigated the effectiveness of morolic acid, a pentacyclic triterpene, on L. amazonensis promastigotes and amastigotes. The present study employed the MTT assay, cytokine analysis using optEIATM kits, an H2DCFDA test, and nitric oxide dosage involving nitrite production and Griess reagent. Morolic acid inhibited promastigote and axenic amastigote growth forms at IC50 values of 1.13 µM and 2.74 µM, respectively. For cytotoxicity to macrophages and VERO cells, morolic acid obtained respective CC50 values of 68.61 µM and 82.94 µM. The compound causes damage to the parasite membrane, leading to cellular leakage. In the infection assay, there was a decrease in parasite load, resulting in a CI50 of 2.56 µM. This effect was associated with immunomodulatory activity, altering macrophage structural and cellular parasite elimination mechanisms. Morolic acid proved to be an effective and selective natural compound, making it a strong candidate for future in vivo studies in cutaneous leishmaniasis. Full article
(This article belongs to the Special Issue Natural Products for Antimicrobial Therapy)
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