Microbiota and Gastrointestinal Diseases

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1584

Special Issue Editor


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Guest Editor
Department of Pediatrics I, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, Gheorghe Marinescu Street, No. 38, 540136 Târgu Mureș, Romania
Interests: pediatrics; pediatric gastroenterology; nutrition; helicobacter pylori infection
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Special Issue Information

Dear Colleagues,

The gastrointestinal (GI) tract hosts a diverse ecosystem of commensal microorganisms known as the gut microbiota, encompassing bacteria, fungi, archaea, and protozoa. This microbiota co-evolves with its host, engaging in critical immunogenic and metabolic interactions essential for health maintenance. However, disruptions in this symbiotic relationship, called dysbiosis, can precipitate various GI disorders including inflammatory bowel disease, colon cancer, celiac disease, and irritable bowel syndrome (IBS). IBS, a prevalent GI disorder characterized by disruptive bowel movements such as diarrhea, constipation, or both, underscores the significant role of gut microbiota in gut health and disease.

This Special Issue aims to investigate how microbiota alterations contribute to disease progression and offers insights into how maintaining microbiota homeostasis can aid in managing GI diseases. As Guest Editors, we invite contributions of research articles, reviews, and short communications that focus on microbiota-related aspects of gastrointestinal diseases. These contributions will enhance our understanding of dysbiosis mechanisms and explore therapeutic approaches aimed at restoring microbiota balance for improved patient outcomes.

We look forward to receiving your contributions.

Best regards,

Dr. Lorena Elena Melit
Guest Editor

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Keywords

  • gut microbiota
  • gastrointestinal diseases
  • gastrointestinal microbiome
  • dysbiosis

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Published Papers (1 paper)

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Review

22 pages, 715 KiB  
Review
Fungi in the Gut Microbiota: Interactions, Homeostasis, and Host Physiology
by Hao-Yu Liu, Shicheng Li, Kennedy Jerry Ogamune, Abdelkareem A. Ahmed, In Ho Kim, Yunzeng Zhang and Demin Cai
Microorganisms 2025, 13(1), 70; https://doi.org/10.3390/microorganisms13010070 - 2 Jan 2025
Viewed by 1069
Abstract
The mammalian gastrointestinal tract is a stage for dynamic inter-kingdom interactions among bacteria, fungi, viruses, and protozoa, which collectively shape the gut micro-ecology and influence host physiology. Despite being a modest fraction, the fungal community, also referred to as mycobiota, represents a critical [...] Read more.
The mammalian gastrointestinal tract is a stage for dynamic inter-kingdom interactions among bacteria, fungi, viruses, and protozoa, which collectively shape the gut micro-ecology and influence host physiology. Despite being a modest fraction, the fungal community, also referred to as mycobiota, represents a critical component of the gut microbiota. Emerging evidence suggests that fungi act as early colonizers of the intestine, exerting a lasting influence on gut development. Meanwhile, the composition of the mycobiota is influenced by multiple factors, with diet, nutrition, drug use (e.g., antimicrobials), and physical condition standing as primary drivers. During its establishment, the mycobiota forms both antagonistic and synergistic relationships with bacterial communities within the host. For instance, intestinal fungi can inhibit bacterial colonization by producing alcohol, while certain bacterial pathogens exploit fungal iron carriers to enhance their growth. However, the regulatory mechanisms governing these complex interactions remain poorly understood. In this review, we first introduce the methodologies for studying the microbiota, then address the significance of the mycobiota in the mammalian intestine, especially during weaning when all ‘primary drivers’ change, and, finally, discuss interactions between fungi and bacteria under various influencing factors. Our review aims to shed light on the complex inter-kingdom dynamics between fungi and bacteria in gut homeostasis and provide insights into how they can be better understood and managed to improve host health and disease outcomes. Full article
(This article belongs to the Special Issue Microbiota and Gastrointestinal Diseases)
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