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Journals
Microorganisms
Special Issues
Neonatal Microbiology
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Neonatal Microbiology

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: 30 December 2024 | Viewed by 847

Special Issue Editors

Prof. Dr. Bernhard Resch

E-Mail Website
Guest Editor
Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34/2, 8036 Graz, Austria
Interests: neonatology; infectious diseases; intensive care medicine; neurodevelopmental follow-up
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Harsharn Gill

E-Mail Website
Guest Editor
Food Research & Innovation Centre, College of Science, Engineering and Health, RMIT University, Melbourne, Australia
Interests: gut microbiome; probiotics and prebiotics; fermented foods; food safety; metabolomics; intestinal and respiratory infections and antimicrobials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the important field of neonatal microbiology. The establishment of the newborn's microbiome is critical to its healthy development. Research has revealed that factors such as birth methods and feeding methods significantly affect the composition and diversity of newborn microorganisms. Early microbial colonization is closely related to the development of the immune system, and an inappropriate microbial environment may increase the risk of infection and disease. In this Special Issue, cutting-edge research explores how to promote neonatal health by regulating microbial communities, highlighting the potential value of interventions such as probiotics. At the same time, it also puts forward prospects for future research directions, aiming to provide more scientific and effective strategies for newborn health care.

For this Special Issue on Microorganisms, we invite you to submit research articles, review articles, brief notes, and communications related to neonatal microbiology. We look forward to receiving your contributions.

Prof. Dr. Bernhard Resch
Prof. Dr. Harsharn Gill
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neonatal
  • newborn
  • microorganisms
  • probiotic

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Published Papers (1 paper)

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Research

11 pages, 271 KiB  
Article
Molecular Biology for Diagnosis of Congenital and Neonatal Infections in the Cerebrospinal Fluid of Newborns from a Brazilian Tertiary Hospital
by Suzana Ferreira Zimmerman, Rodrigo Gonçalves de Lima, André Moreno Morcillo, Sandra Helena Alves Bonon and Sergio Tadeu Martins Marba
Microorganisms 2024, 12(11), 2133; https://doi.org/10.3390/microorganisms12112133 - 24 Oct 2024
Viewed by 597
Abstract
The risk of infection transmission from mother to fetus depends on the pathogen. TORCH agents cause some neuroinfections, including Toxoplasmosis, rubella, Cytomegalovirus, herpes simplex 1 and 2, and others (Varicella Zoster, Parvovirus B-19, Epstein–Barr virus, and Zika virus). The consequences can be stillbirth, [...] Read more.
The risk of infection transmission from mother to fetus depends on the pathogen. TORCH agents cause some neuroinfections, including Toxoplasmosis, rubella, Cytomegalovirus, herpes simplex 1 and 2, and others (Varicella Zoster, Parvovirus B-19, Epstein–Barr virus, and Zika virus). The consequences can be stillbirth, prematurity, uterine growth restriction, and congenital malformations. The detection of DNA/RNA from CSF by molecular methods is a marker of the involvement of congenital infection in the central nervous system. This study aimed to identify the frequency of these pathogens in CSF samples from newborns (1 to 28 days old) at a tertiary hospital, using PCR, and determine the clinical consequences. Methods: This was a prospective descriptive study involving the molecular analysis of 151 CSF samples from neonates, collected for cytological and biochemical diagnosis from 2017 to 2021. After the results and consent from the participants’ caregivers were obtained, the leftover material was sent to the University’s Virology Laboratory and submitted for DNA/RNA extraction and Nested-PCR/RT-PCR. A review of the patients’ medical records and descriptive statistics was performed. This work was approved by the Ethics Committee (CAAE: 86760218.3.0000.5404). Results: A total of 151 CSF samples were obtained, 16 of which were positive (10.6% [95% CI%: 6.18–16.63%]). Two of these were PCR-positive for HSV-1 (1.3%), four for VZV (2.6%), one for CMV (0.67%), two for Toxoplasmosis (1.3%), four for Parvovirus B-19 (2.6%), and four for Zika (2.6%). The proportion of positive PCR results was higher in the group that presented with malformations (25.0% vs. 8.4%, p = 0.040). Conclusions: The pathogens identified by PCR were mostly Zika virus, VZV, and B-19, and these were mainly found in newborns with malformations. Full article
(This article belongs to the Special Issue Neonatal Microbiology)
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