Bacterial Pathogenesis and Host Immune Responses

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1366

Special Issue Editor


E-Mail Website
Guest Editor
College of Life Sciences, Nankai University, Tianjin, China
Interests: pathogenic mechanism of pathogenic microorganism infection and host immunity

Special Issue Information

Dear Colleagues,

Pathogenic bacteria are major causes of morbidity and mortality worldwide. The significance of research into their pathogenesis and the host immune responses cannot be emphasized enough. In this Special Issue, we invite papers that focus on identifying and analyzing the factors that enable bacteria to cause diseases in their hosts, examining the molecular and cellular interactions between pathogenic bacteria and their hosts, exploring how bacteria develop resistance to antibiotics and identifying strategies to combat this escalating global challenge, designing and developing vaccines that can stimulate protective immune responses against pathogenic bacteria, understanding how pathogenic bacteria spread and trigger outbreaks, and identifying risk factors and prevention strategies. These studies will contribute significantly to our understanding of the disease mechanisms, the development of therapeutic strategies, the prevention and control of infectious diseases, the advancement of scientific knowledge, and, finally, the improvement in public health outcomes.

In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Prof. Dr. Zhihui Cheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • host–pathogen interactions
  • pathogenic bacteria
  • pathogenesis
  • bacterial infections
  • disease mechanisms
  • host immune responses
  • inflammatory responses 
  • vaccine development
  • antimicrobial resistance
  • therapeutic strategies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 5395 KiB  
Article
Impact of Mycobacterium tuberculosis H37Rv Infection on Extracellular Vesicle Cargo in Macrophages: Implications for Host–Pathogen Interaction
by Manuel G. Salgado-Cantú, Luis Horacio Gutiérrez-González, Silvia Guzmán-Beltrán, María Teresa Herrera, Carmen Sarabia and Yolanda González
Microorganisms 2024, 12(12), 2405; https://doi.org/10.3390/microorganisms12122405 - 23 Nov 2024
Viewed by 852
Abstract
Tuberculosis (TB) is one of the most common respiratory infections worldwide, and it is caused by Mycobacterium tuberculosis (Mtb). Mtb employs immune evasion mechanisms that allow the disease to become chronic. Despite extensive research, the host–pathogen interaction remains incompletely understood. Extracellular [...] Read more.
Tuberculosis (TB) is one of the most common respiratory infections worldwide, and it is caused by Mycobacterium tuberculosis (Mtb). Mtb employs immune evasion mechanisms that allow the disease to become chronic. Despite extensive research, the host–pathogen interaction remains incompletely understood. Extracellular vesicles (EVs) are small membrane particles that play a regulatory role in infectious diseases. Host-derived EVs have been identified as carriers of proteins, messenger RNA, and lipids from both the host cells and the pathogens. In this study, we assessed the cargo of EVs in human macrophages infected with the virulent strain H37Rv of Mtb at 1 and 24 h post-infection (hpi). The results showed that 1 hpi, infected macrophages secreted EVs containing Mtb proteins (15 to 37 kDa) and Ag85 kDa, as well as RNA transcripts (ESAT-6, 5KST, Ag85, IS6110, 30 kDa, 19 kDa, and MPT64). However, these decreased at 24 hpi. The infection of macrophages with Mtb was observed to result in the release of EVs containing Ag85 protein and RNA transcripts of Mtb; this process appeared to diminish after 24 hpi, suggesting the existence of an evasion mechanism. Both Ag85 and the RNA transcripts could be potential biomarkers for the diagnosis of TB patients. Full article
(This article belongs to the Special Issue Bacterial Pathogenesis and Host Immune Responses)
Show Figures

Figure 1

Back to TopTop