Correlations Between the Gastrointestinal Microbiome and Diseases

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1959

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Guest Editor
Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
Interests: microbiology; bacterial infectious diseases; zoonosis; intestinal microbiome; inflammatory bowel diseases; vector-borne disease
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Special Issue Information

Dear Colleagues,

In humans and animals, the microbiome is often used to describe the microorganisms that live in or on a particular part of the body, such as the skin, lungs, or gastrointestinal tract. Due to their significant number and importance, the gut microbiome is characterized as an “organ.” This microbial community is essential to the normal form and function of the host in a range of physiologic processes, including energy homeostasis, metabolism, gastrointestinal epithelial health, immunologic activity, and neurobehavioral development and functions. Thus, the frontier findings of the role of gut microbiota in the host’s health and disease development have become crucial for future disease prevention, diagnosis, and treatment.

In this Special Issue, we aim to assemble a collection of research articles, reviews, and case reports that highlight the critical advancements in our understanding of the role of gastrointestinal microbiome in their host’s health and diseases. Your research has the potential to significantly impact the field of microbiology, and we are eager to include your valuable contributions. For this purpose, we cordially invite you to submit articles related to the various aspects of correlations between the gastrointestinal microbiome and diseases.

Dr. Jilei Zhang
Guest Editor

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Keywords

  • gut microbes
  • microbiome
  • host health
  • diseases
  • gastroenterology

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Published Papers (2 papers)

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Research

14 pages, 2412 KiB  
Article
Gastric Microbiota Associated with Gastric Precancerous Lesions in Helicobacter pylori-Negative Patients
by Han-Na Kim, Min-Jeong Kim, Jonathan P. Jacobs and Hyo-Joon Yang
Microorganisms 2025, 13(1), 81; https://doi.org/10.3390/microorganisms13010081 - 3 Jan 2025
Viewed by 728
Abstract
Studies on the gastric microbiota associated with gastric precancerous lesions remain limited. This study aimed to profile the gastric mucosal microbiota in patients with Helicobacter pylori-negative precancerous lesions. Gastric mucosal samples were obtained from 67 H. pylori-negative patients, including those with [...] Read more.
Studies on the gastric microbiota associated with gastric precancerous lesions remain limited. This study aimed to profile the gastric mucosal microbiota in patients with Helicobacter pylori-negative precancerous lesions. Gastric mucosal samples were obtained from 67 H. pylori-negative patients, including those with chronic gastritis (CG), intestinal metaplasia (IM), and dysplasia. The V3–V4 region of the 16S rRNA gene was sequenced and analyzed. No significant difference was observed in the alpha or beta diversity of the gastric microbiota among the groups. However, a taxonomic analysis revealed a significant enrichment of Lautropia mirabilis and the depletion of Limosilactobacillus reuteri, Solobacxterium moorei, Haemophilus haemolyticus, and Duncaniella dubosii in the IM and dysplasia groups compared to those in the CG group. Prevotella jejuni and the genus Parvimonas were enriched in the IM group. A predictive functional analysis revealed enrichment of the ornithine degradation pathway in the IM and dysplasia groups, suggesting its role in persistent gastric mucosal inflammation associated with gastric precancerous lesions. The gastric microbiota associated with H. pylori-negative gastric precancerous lesions showed an increased abundance of oral microbes linked to gastric cancer and a reduction in anti-inflammatory bacteria. These alterations might contribute to chronic gastric mucosal inflammation, promoting carcinogenesis in the absence of H. pylori infection. Full article
(This article belongs to the Special Issue Correlations Between the Gastrointestinal Microbiome and Diseases)
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18 pages, 4157 KiB  
Article
Network Analysis of Pathogenesis Markers in Murine Chagas Disease Under Antimicrobial Treatment
by Nayra Dias, Marina Dias, Andressa Ribeiro, Nélio Gomes, Aline Moraes, Moisés Wesley, Carlito Gonzaga, Doralina do Amaral Rabello Ramos, Shélida Braz, Bruno Dallago, Juliana Lott de Carvalho, Luciana Hagström, Nadjar Nitz and Mariana Hecht
Microorganisms 2024, 12(11), 2332; https://doi.org/10.3390/microorganisms12112332 - 15 Nov 2024
Viewed by 894
Abstract
Chagas disease (CD), a disease affecting millions globally, remains shrouded in scientific uncertainty, particularly regarding the role of the intestinal microbiota in disease progression. This study investigates the effects of antibiotic-induced microbiota depletion on parasite burden, immune responses, and clinical outcomes in BALB/c [...] Read more.
Chagas disease (CD), a disease affecting millions globally, remains shrouded in scientific uncertainty, particularly regarding the role of the intestinal microbiota in disease progression. This study investigates the effects of antibiotic-induced microbiota depletion on parasite burden, immune responses, and clinical outcomes in BALB/c mice infected with either the Trypanosoma cruzi Colombiana or CL Brener strains. Mice were treated with a broad-spectrum antibiotic cocktail before infection, and parasite burden was quantified via qPCR at 30 and 100 days post-infection (dpi). Immune responses were analyzed using flow cytometry and ELISA, while histopathology was conducted on cardiac and intestinal tissues. Antibiotic treatment uncovered strain-specific correlations, with Colombiana infections affecting Bifidobacterium populations and CL Brener infections linked to Lactobacillus. Microbiota depletion initially reduced parasite burden in the heart and intestine, but an increase was observed in the chronic phase, except in the CL Brener-infected gut, where an early burden spike was followed by a decline. Antibiotic-induced bacterial shifts, such as reductions in Bacteroides and Bifidobacterium, promoted a more pro-inflammatory immune profile. These findings highlight the importance of microbiota and strain-specific factors in CD and suggest further research into microbiota manipulation as a potential therapeutic strategy. Full article
(This article belongs to the Special Issue Correlations Between the Gastrointestinal Microbiome and Diseases)
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