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Molecules
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Chitosan-Based Materials and Its Potential in Cosmetic and Biomedical Applications
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Chitosan-Based Materials and Its Potential in Cosmetic and Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 5726

Special Issue Editor

Prof. Dr. Katarzyna Lewandowska

E-Mail Website
Guest Editor
Department of Chemistry of Biomaterials and Cosmetics, Faculty of Chemistry, Nicolaus Copernicus in Toruń, Gagarina 7, 87-100 Toruń, Poland
Interests: biomaterials based on chitosan; chitosan derivatives; chitin; hyaluronic acid; gum and synthetic polymers, i.e., poly(vinyl alcohol), poly(N-vinylpyrrolidone), polyacrylamide, and partially hydrolyzed polyacrylamide; modification of polymer properties; miscibility and physicochemical properties of polymer blends containing biopolymers; preparation and characterization of polymer blends and composites; rheological properties of polymers and their mixtures; ionic liquids; rheological properties of cosmetic forms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biopolymers are extensively used in the cosmetic industry as raw materials and show great potential for biomedical applications due to their film-forming ability, controlled bioactivity, biocompatibility, and natural origin. Chitosan (CS) is a polysaccharide and the main derivative of chitin, commonly found in the exoskeletons of crustaceans and insects. It is a copolymer of glucosamine and N-acetylglucosamine connected by a β (1-4) linkage.

This Special Issue is oriented towards all functional materials based on chitosan that, on the one hand, align with sustainability and circular economy principles and, on the other hand, exhibit improved performance. Authors are encouraged to present new materials based on chitosan and its derivatives, including polymer blends, composites, scaffolds, thin films, and hydrogels that are economically and environmentally friendly while delivering good overall performance. The scope of the Special Issue, therefore, encompasses the manufacturing and characterization of polymer materials used in biomedical, pharmaceutical, and cosmetic applications.

Prof. Dr. Katarzyna Lewandowska
Guest Editor

Manuscript Submission Information

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Keywords

  • chitosan
  • chitosan derivatives
  • polysaccharides
  • biopolymers
  • films
  • hydrogels
  • hybrid materials
  • 3D porous structures
  • biomaterials
  • biopolymer blends
  • composites

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Published Papers (3 papers)

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Research

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19 pages, 5069 KiB  
Article
From Bioink to Tissue: Exploring Chitosan-Agarose Composite in the Context of Printability and Cellular Behaviour
by Szymon Mania, Adrianna Banach-Kopeć, Natalia Maciejewska, Katarzyna Czerwiec, Paulina Słonimska, Milena Deptuła, Jakub Baczyński-Keller, Michał Pikuła, Paweł Sachadyn and Robert Tylingo
Molecules 2024, 29(19), 4648; https://doi.org/10.3390/molecules29194648 - 30 Sep 2024
Viewed by 1065
Abstract
This study presents an innovative method for producing thermosensitive bioink from chitosan hydrogels saturated with carbon dioxide and agarose. It focuses on a detailed characterisation of their physicochemical properties and potential applications in biomedicine and tissue engineering. The ORO test approved the rapid [...] Read more.
This study presents an innovative method for producing thermosensitive bioink from chitosan hydrogels saturated with carbon dioxide and agarose. It focuses on a detailed characterisation of their physicochemical properties and potential applications in biomedicine and tissue engineering. The ORO test approved the rapid regeneration of the three-dimensional structure of chitosan–agarose composites in a unidirectional bench press simulation test. The diffusion of dyes through the chitosan–agarose hydrogel membranes strongly depended on the share of both polymers in the composite and the molecular weight of the dyes. Glucose, as a nutrient marker, also diffused through all membranes regardless of composition. Biocompatibility assessment using MTT tests on 46BR.1N fibroblasts and HaCaT keratinocytes confirmed the safety of the bioink. The regenerative potential of the bioink was confirmed by efficient cell migration, especially HaCaT. Long-term viability studies showed that chitosan–agarose scaffolds, unlike the agarose ones, support cell proliferation and survival, especially 14 days after bioink extrusion. Experiments in a skin wound model in mice confirmed the biocompatibility of the tested dressing and the beneficial action of chitosan on healing. Studies on vessel formation in chicken embryos highlight the potential of the chitosan–agarose composition to enhance proangiogenic effects. This composition meets all entry criteria and possesses excellent biological properties. Full article
(This article belongs to the Special Issue Chitosan-Based Materials and Its Potential in Cosmetic and Biomedical Applications)
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12 pages, 1577 KiB  
Article
Physical Properties and Release Profiles of Chitosan Mixture Films Containing Salicin, Glycerin and Hyaluronic Acid
by Katarzyna Lewandowska, Alina Sionkowska and Marzanna Kurzawa
Molecules 2023, 28(23), 7827; https://doi.org/10.3390/molecules28237827 - 28 Nov 2023
Cited by 2 | Viewed by 1272
Abstract
Chitosan (CS) has gained considerable attention due to its distinctive properties and its broad spectrum of potential applications, spanning cosmetics, pharmaceuticals, and biomedical uses. In this study, we characterized thin films comprising chitosan mixtures containing salicin (SAL) and glycerin (GLY), both with and [...] Read more.
Chitosan (CS) has gained considerable attention due to its distinctive properties and its broad spectrum of potential applications, spanning cosmetics, pharmaceuticals, and biomedical uses. In this study, we characterized thin films comprising chitosan mixtures containing salicin (SAL) and glycerin (GLY), both with and without hyaluronic acid (HA) as active ingredients. Characterization was achieved through release studies of SAL, infrared spectroscopy, microscopy techniques (AFM and SEM), and thermogravimetric analysis (TGA). CS/GLY/SAL and CS/GLY/SAL/HA mixture films were fabricated using the solvent evaporation technique. We probed interactions between the components in the chitosan mixtures via infrared analysis. The concentration of released salicin was monitored at various time intervals in a phosphate buffer (PBS) at pH 5.5 using HPLC. The linear regression analysis for the calibration graph showed a good linear relationship (R2 = 0.9996) in the working concentration range of 5–205 mg/dm3. Notably, the release of SAL reached its peak after 20 min. Furthermore, the introduction of HA caused changes in the films’ morphology, but their roughness remained largely unchanged. The results obtained were compared, indicating that the release of SAL in the CS mixture films is sufficient for diverse applications, including wound-healing materials and cosmetic beauty masks. Full article
(This article belongs to the Special Issue Chitosan-Based Materials and Its Potential in Cosmetic and Biomedical Applications)
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Review

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29 pages, 1578 KiB  
Review
Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels
by Weronika Kruczkowska, Karol Kamil Kłosiński, Katarzyna Helena Grabowska, Julia Gałęziewska, Piotr Gromek, Mateusz Kciuk, Żaneta Kałuzińska-Kołat, Damian Kołat and Radosław A. Wach
Molecules 2024, 29(18), 4360; https://doi.org/10.3390/molecules29184360 - 13 Sep 2024
Cited by 1 | Viewed by 2516
Abstract
Carboxymethyl chitosan (CMCS) hydrogels have been investigated in biomedical research because of their versatile properties that make them suitable for various medical applications. Key properties that are especially valuable for biomedical use include biocompatibility, tailored solid-like mechanical characteristics, biodegradability, antibacterial activity, moisture retention, [...] Read more.
Carboxymethyl chitosan (CMCS) hydrogels have been investigated in biomedical research because of their versatile properties that make them suitable for various medical applications. Key properties that are especially valuable for biomedical use include biocompatibility, tailored solid-like mechanical characteristics, biodegradability, antibacterial activity, moisture retention, and pH stimuli-sensitive swelling. These features offer advantages such as enhanced healing, promotion of granulation tissue formation, and facilitation of neutrophil migration. As a result, CMCS hydrogels are favorable materials for applications in biopharmaceuticals, drug delivery systems, wound healing, tissue engineering, and more. Understanding the interactions between CMCS hydrogels and biological systems, with a focus on their influence on cellular behavior, is crucial for leveraging their versatility. Because of the constantly growing interest in chitosan and its derivative hydrogels in biomedical research and applications, the present review aims to provide updated insights into the potential medical applications of CMCS based on recent findings. Additionally, we comprehensively elucidated the cellular mechanisms underlying the actions of these hydrogels in medical settings. In summary, this paper recapitulates valuable data gathered from the current literature, offering perspectives for further development and utilization of carboxymethyl hydrogels in various medical contexts. Full article
(This article belongs to the Special Issue Chitosan-Based Materials and Its Potential in Cosmetic and Biomedical Applications)
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