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The Chemistry, Bioactivity and Analysis of Essential Oils: Applications for Foods, Drugs and Cosmetics

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1573

Special Issue Editors


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Guest Editor
National Research Council (CNR), Institute of Biosciences and Bio-Resources (IBBR), Via P. Castellino 111, 80131 Naples, Italy
Interests: plant diversity; food safety and quality; food science; phyto-bioactive compounds
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Theoretical and Applied Sciences, E-Campus University, Novedrate, 22060 Como, Italy
Interests: nutraceuticals; phytochemicals; secondary metabolites; natural products; essential oils; citrus; LC-MS; HRGC/HRMS
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
National Research Council (CNR), Institute of Food Sciences (ISA) via Roma, 64-83100 Avellino, Italy
Interests: food analytical chemistry; phytochemicals; polyphenols; lipids; essential oils; GC; LC; MS; FT-IR

Special Issue Information

Dear Colleagues,

Essential Oils (EOs) are complex mixtures of volatile compounds found in plant structures, giving them their characteristic odour. They are intimately involved in vital processes within the plant, performing very important functions. They play a defensive role, act as insect repellents and microbial inhibitors and attract pollinating insects.

EOs are extracted for food, pharmaceutical and cosmetic applications due to their unique odour characteristics and proven antioxidant and antimicrobial properties.

Many herbs and spices (e.g., black cumin, cloves, cinnamon, thyme, rosemary, etc.) have been studied for their content of important EOs. In other plant species, such as citrus fruits, hemp, rose, garlic, onion, pepper, peppermint, vanilla and lavender, different parts, such as the fruits, leaves, roots, bark and seeds, are used for the extraction of EOs. EOs are generally obtained by steam distillation, although those from the citrus genus are mechanically extracted.

Numerous studies have reported that EOs possess a wide range of bioactivities, and these activities have been attributed to some specific constituents. Research interest in EOs continues to grow with the identification of new molecular targets and the development of new screening methods. Therefore, analytical techniques to study the chemistry of essential oils are evolving accordingly.

This Special Issue will be a collection of original research articles and critical reviews on the different chemical and bioactivity properties of essential oils from the whole plant kingdom.

From a chemical perspective, topics related to advances in new and past extraction methods, with particular attention to technologies, and essential oil analysis are encouraged.

From a biological point of view, studies that explore the routes by which these oils or some of their individual components exert their bioactive actions for human or plant purposes are recommended, rather than studies dealing only with the antioxidant properties of essential oils.

Articles in this Special Issue should be of relevance to a wide international readership and meet all the normal requirements for publication in Molecules.

Dr. Bruna Laratta
Dr. Domenico Cautela
Dr. Francesco Siano
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • essential oils
  • volatile compounds
  • bioactivity
  • extraction methods
  • innovative and conventional techniques
  • natural food preservatives
  • industrial application

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Published Papers (1 paper)

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Research

15 pages, 1124 KiB  
Article
Chemical Composition and Antibacterial, Antioxidant, and Cytotoxic Activities of Essential Oils from Leaves and Stems of Aeschynomene indica L.
by Linjie Feng, Fan Xu, Shu Qiu, Chengqi Sun and Pengxiang Lai
Molecules 2024, 29(15), 3552; https://doi.org/10.3390/molecules29153552 - 28 Jul 2024
Viewed by 1210
Abstract
The objective of this study was to analyze the chemical composition and evaluate the biological capabilities of the essential oils (EOs) extracted from leaves and stems of wild Aeschynomene indica L. plants by the hydrodistillation method. By using GC-FID/MS, fifty-six and fifty-five compounds, [...] Read more.
The objective of this study was to analyze the chemical composition and evaluate the biological capabilities of the essential oils (EOs) extracted from leaves and stems of wild Aeschynomene indica L. plants by the hydrodistillation method. By using GC-FID/MS, fifty-six and fifty-five compounds, representing 95.1 and 97.6% of the essential oils in the leaves and stems, respectively, were characterized. The predominant constituents of A. indica EOs were (E)-caryophyllene, linalool, viridiflorol, phytol, hexadecanoic acid, trans-verbenol, and α-guaiene. The antibacterial and synergistic activities of the EOs were assessed by microdilution and checkerboard assays. The results revealed a potent inhibition and bactericidal activity against Staphylococcus aureus and Bacillus subtilis with MICs of 0.312–0.625 mg/mL. When combined with traditional antibiotics, the essential oils of A. indica possessed excellent synergistic effects against all tested bacteria. Additionally, the EOs of A. indica leaves showed higher antioxidant activity (IC50 = 0.11 ± 0.01 µg/mL) compared to the stem oil (IC50 = 0.19 ± 0.01 µg/mL) using the ABTS radical scavenging assay. The in vitro cytotoxicity of EOs against human cancer cell lines HepG2, MCF-7, A-549, and HCT-116 was examined, and MTT assays showed that the EOs possessed a significant cytotoxic potential against MCF-7 breast cancer cells, with IC50 values of 10.04 ± 1.82 and 15.89 ± 1.66 μg/mL, and a moderate cytotoxic activity against other tested cells. In conclusion, the A. indica EOs could be considered a potential source of pharmacologically active compounds. Full article
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