The Role of Peptides and Peptidomimetics in Drug Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1236
Special Issue Editor
Interests: organic chemistry; medicinal chemistry; small molecules; drug-like compounds; tethered and fused diazacyclic compounds; heterocyclic peptidomimetics; combinatorial chemistry; solid phase organic synthesis
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Special Issue Information
Dear Colleagues,
Peptide and Peptidomimetic drug discovery has progressed tremendously over the last two decades to become an extraordinary field which has resulted in a substantial body of multidisciplinary research. It has engaged synthetic, computational, and biophysical chemists, biochemists, pharmacologists, and drug development scientists worldwide to create novel molecule lead compounds, clinical candidates, and breakthrough medicines. Immense efforts have been dedicated towards developing therapeutic entities that can modulate intracellular proteins. Molecules that can readily cross cell membranes are becoming a frequent need in biological research, drug discovery, and medicine. A wide variety of natural peptides and peptidomimetics have been obtained and studied, and many others are advancing through clinical trials, covering multiple therapeutic areas.
Taking advantage of the diversity within the amino acid functionalities and stereochemistry that are commercially available as standard Fmoc/Boc amino acids, as well as the benefits of solid phase peptide synthesis, various synthetic strategies have been developed over the years to modulate the conformational flexibility and the peptide character of peptidomimetic compounds. This Special Issue calls for papers to elucidate the most effective strategy for the synthesis of peptides, cyclic peptides, and peptidomimetics, and the use of such approaches in the identification of active therapeutics with peptide structures.
Prof. Dr. Adel Nefzi
Guest Editor
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Keywords
- peptide synthesis
- peptide therapeutics
- cyclic peptides
- peptidomimetics
- peptide drug discovery
- modified peptides
- bioactive peptides
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