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Phytochemical Profiling, Bioactivity, Biotechnology Studies and Practical Applications of Medicinal and Cosmetic Plants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1386

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland
Interests: pharmaceutical botany; plant biotechnology; phytochemistry; medicinal plants; cosmetic plants; natural products; bioactive compounds (especially lignans, phenolic acids, flavonoids); ethnobotany; ethnopharmacology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Institute of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Cracow, Poland
Interests: plant material extraction; cosmetic chemistry and technology; metabolites analysis; polyphenols isolation and purification

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Guest Editor Assistant
Section of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece
Interests: pharmacognosy; natural products chemistry; natural extracts characterization; profiling; bioactivity; metabolomics; isolation; ethnopharmacology; food chemistry; molecular networking; cosmetics

Special Issue Information

Dear Colleagues,

Natural products originating from the plant kingdom offer an unexplored opportunity for potential medicinal, health promoting, and cosmetic applications.

In recent years, special attention has been given to the isolation of individual plant-derived compounds, as well as searching for related innovative and alternative biotechnological methods.

Plant extracts and/or isolated compounds exhibiting numerous directions of biological activities, such as anti-inflammatory, anticancer, immunostimulating, or antimicrobial effects, as well as cardioprotective, neuroprotective, and antidiabetic activities, are also very significant. The cosmetic application of natural compounds (including anti-aging, antioxidant, brightening, protective, stimulating the synthesis of structural skin proteins, and supporting its natural renewal mechanisms) is gaining increasing importance. Identifying the key metabolites of plant extracts and utilizing them in the form of specialized topical formulations allows for the preservation of their biological activity and the maintenance of the effectiveness of the functional ingredients.

The main aim of the Special Issue, entitled “Phytochemical Profiling, Bioactivity, Biotechnology Studies and Practical Applications of Medicinal and Cosmetic Plants”, is to present the newest results of investigations and findings in the above-presented field. Results presenting the correlation between the chemical composition of extracts and/or isolated compounds or in vitro culture biomass and their biological activity are of high interest.

Original papers or review articles are welcome.

Prof. Dr. Agnieszka Szopa
Guest Editors

Dr. Magdalena Anna Malinowska
Dr. Ekaterina-Michaela Tomou
Guest Editor Assistant

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant metabolites
  • plant biotechnology
  • bioactive natural compounds
  • natural products metabolomics
  • pharmacological activity of natural compounds
  • cosmetic applications of natural compounds
  • isolation of natural compounds
  • essential oils
  • biological activity of natural compounds
  • in vitro approach
  • in vivo approach
  • clinical investigations
  • ethnopharmacological indications
  • ethnobotanical indications
  • technology of cosmetic formulations
  • skin permeability
  • irritating potential
  • agricultural practices

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Published Papers (1 paper)

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Research

24 pages, 7360 KiB  
Article
Phytochemical Analysis, Biological Activities, and Docking of Phenolics from Shoot Cultures of Hypericum perforatum L. Transformed by Agrobacterium rhizogenes
by Oliver Tusevski, Marija Todorovska, Jasmina Petreska Stanoeva and Sonja Gadzovska Simic
Molecules 2024, 29(16), 3893; https://doi.org/10.3390/molecules29163893 - 17 Aug 2024
Viewed by 1072
Abstract
Hypericum perforatum transformed shoot lines (TSL) regenerated from corresponding hairy roots and non-transformed shoots (NTS) were comparatively evaluated for their phenolic compound contents and in vitro inhibitory capacity against target enzymes (monoamine oxidase-A, cholinesterases, tyrosinase, α-amylase, α-glucosidase, lipase, and cholesterol esterase). Molecular docking [...] Read more.
Hypericum perforatum transformed shoot lines (TSL) regenerated from corresponding hairy roots and non-transformed shoots (NTS) were comparatively evaluated for their phenolic compound contents and in vitro inhibitory capacity against target enzymes (monoamine oxidase-A, cholinesterases, tyrosinase, α-amylase, α-glucosidase, lipase, and cholesterol esterase). Molecular docking was conducted to assess the contribution of dominant phenolic compounds to the enzyme-inhibitory properties of TSL samples. The TSL extracts represent a rich source of chlorogenic acid, epicatechin and procyanidins, quercetin aglycone and glycosides, anthocyanins, naphthodianthrones, acyl-phloroglucinols, and xanthones. Concerning in vitro bioactivity assays, TSL displayed significantly higher acetylcholinesterase, tyrosinase, α-amylase, pancreatic lipase, and cholesterol esterase inhibitory properties compared to NTS, implying their neuroprotective, antidiabetic, and antiobesity potential. The docking data revealed that pseudohypericin, hyperforin, cadensin G, epicatechin, and chlorogenic acid are superior inhibitors of selected enzymes, exhibiting the lowest binding energy of ligand–receptor complexes. Present data indicate that H. perforatum transformed shoots might be recognized as an excellent biotechnological system for producing phenolic compounds with multiple health benefits. Full article
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