The Impact of Metal Complexes with Active Small Molecules in Biological Systems
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 123
Special Issue Editors
Interests: coordination chemistry; polyphenols; coordination compounds; metalloproteins; oxidative stress; iron; free radicals; spectroscopy; biochemistry; bioinorganic chemistry; DNA interactions; antioxidants; antioxidant assays; inorganic biochemistry; inorganic chemistry; coordination chemistry and metal complexes; lanthanide; synthesis; electronic structure; inorganic synthesis; organometallics; circular dichroism; electron spin resonance spectroscopy; flavonoids; apoptosis; organic synthesis; nitric oxide; structural biology; phenolic compounds; thiols; genotoxicity
Special Issues, Collections and Topics in MDPI journals
Interests: radiochemistry; inorganic chemistry; chemical analytics; cellular response; cytotoxicity; radiobiology; radiopharmacy; targeting chemical compounds to the tumor phenotype
Special Issue Information
Dear Colleagues,
This Issue will focus on the newest findings on metal complexes with active small molecules (M-ASM) in biological systems. This publication will discuss all aspects of signalling and regulatory functions of metal complexes with active small molecules, including redox status modulation and anti/pro-oxidant activities, protein induction and inhibition. Tentative subjects include (but are not limited to) the following:
- Turnover, metabolism, and interconversions of metal complexes with active small molecules (M-ASMs):
- Synthesis: How M-ASMs are produced in cells, including the enzymes and metabolic pathways involved.
- Degradation: How M-ASMs are broken down in cells, including the enzymes and metabolic pathways involved.
- Interconversions: How M-ASMs are converted into different forms, including the enzymes and metabolic pathways involved.
- Signaling and regulatory functions of M-ASMs:
- Metallic cellular targets of ASMs.
- Metal cofactor-driven signaling mechanisms.
- Oxidation state-related cellular aspects of M-ASM-dependent signaling.
- M-ASM-related cancer-signaling pathways.
- Correlation between the structural features of ASMs and their metal complexes with their biological activity:
- How geometry and ligand properties of an ASM can affect its interactions with metal ions and other molecules in the cell.
- How the periodic properties and oxidation state of the metal ion can affect the activity of the ASM-metal complex.
- How the structure of the ASM-metal complex can affect its specificity for different cellular targets.
- M-ASM potential applications in cellular therapeutics:
- How M-ASMs can be used to develop new drugs and therapies for diseases such as cancer and Alzheimer's disease.
- How M-ASMs can be used to develop new strategies for DNA-targeted therapy.
- How M-ASMs can be used to develop new tools for diagnosing and monitoring diseases.
Both review and original papers are welcome. Authors are encouraged to suggest any other aspects of the M-ASM-related cellular activity, according to their knowledge and expertise.
Dr. Hanna Lewandowska
Dr. Karolina E. Wójciuk
Guest Editors
Manuscript Submission Information
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Keywords
- metal complexes
- active small molecules
- biological systems
- signaling and regulatory functions
- DNA-targeted therapy
- new drugs and therapies
- cellular therapeutics
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