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Applied Sciences
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Metals and Metal Complexes in Cell Signaling
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Metals and Metal Complexes in Cell Signaling

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 10725

Special Issue Editor

Dr. Hanna Lewandowska

E-Mail Website1 Website2
Guest Editor
School of Health & Medical Sciences, University of Economics and Human Sciences in Warsaw, Okopowa 59, 01-043 Warsaw, Poland
Interests: coordination chemistry; polyphenols; coordination compounds; metalloproteins; oxidative stress; iron; free radicals; spectroscopy; biochemistry; bioinorganic chemistry; DNA interactions; antioxidants; antioxidant assays; inorganic biochemistry; inorganic chemistry; coordination chemistry and metal complexes; lanthanide; synthesis; electronic structure; inorganic synthesis; organometallics; circular dichroism; electron spin resonance spectroscopy; flavonoids; apoptosis; organic synthesis; nitric oxide; structural biology; phenolic compounds; thiols; genotoxicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Issue will focus on the newest findings about the role of metals in cell signaling, including all aspects of signal reception, transduction, and response. The tentative subjects include the following:

metal cofactor-driven signaling mechanisms,
oxidation state-related cellular aspects of metal-dependent signaling,
oxidative stress and its role in metal-related cellular signaling pathways,
the influence of metals on cell homeostasis,
mechanisms of regulation of the metal levels in cells,
the influence of heavy metals on cellular regulation pathways,
metal-related cancer-signaling pathways,
metal-binding sites in proteins,
metallic sites regulation by signaling molecules,
special roles of metals in the organs analyzed at a cellular level,
metallic and metal-sensing probes applied in monitoring of cellular processes.

Both review and original papers are welcome. Authors are encouraged to suggest any other aspects of the metal-related cell signaling, according to their knowledge and expertise.

Dr. Hanna Lewandowska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metals
  • cofactors
  • cell signaling pathways
  • metal-binding sites
  • redox regulation
  • molecular probes

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Published Papers (3 papers)

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Research

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12 pages, 3021 KiB  
Article
Co(II) Complex of Quercetin–Spectral, Anti-/Pro-Oxidant and Cytotoxic Activity in HaCaT Cell Lines
by Monika Kalinowska, Hanna Lewandowska, Marek Pruszyński, Grzegorz Świderski, Ewelina Gołębiewska, Kamila Gryko, Julia Braun, Monika Borkowska, Magda Konieczna and Włodzimierz Lewandowski
Appl. Sci. 2021, 11(19), 9244; https://doi.org/10.3390/app11199244 - 4 Oct 2021
Cited by 7 | Viewed by 2769
Abstract
In this study a cobalt(II) complex of quercetin was synthetized in the solid state with the general formula Co(C15H9O7)2∙2H2O. The FT-IR, elemental analysis, and UV/Vis methods were used to study the composition of [...] Read more.
In this study a cobalt(II) complex of quercetin was synthetized in the solid state with the general formula Co(C15H9O7)2∙2H2O. The FT-IR, elemental analysis, and UV/Vis methods were used to study the composition of the complex in a solid state and in a water solution. The anti-/pro-oxidant activity of quercetin and the Co(II) complex was studied by means of spectrophotometric DPPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (ferric reducing antioxidant activity) and Trolox oxidation assays. The cytotoxicity of quercetin and Co(II)-quercetin complex in HaCat cell lines was then established. Full article
(This article belongs to the Special Issue Metals and Metal Complexes in Cell Signaling)
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Review

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13 pages, 276 KiB  
Review
An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling
by Wolfgang Maret
Appl. Sci. 2021, 11(22), 10846; https://doi.org/10.3390/app112210846 - 17 Nov 2021
Cited by 9 | Viewed by 2661
Abstract
Humans require about 20 chemical elements. Half of them are essential metal ions. Many additional, non-essential metal ions are present in our bodies through environmental exposures, including in our diet, with functional consequences. Their accumulation is accelerated due to the increasing pollution of [...] Read more.
Humans require about 20 chemical elements. Half of them are essential metal ions. Many additional, non-essential metal ions are present in our bodies through environmental exposures, including in our diet, with functional consequences. Their accumulation is accelerated due to the increasing pollution of soil, air, water and manufacturing processes that employ chemical elements to which we have not been exposed in our evolutionary history. Yet other metal ions are essential for other forms of life, which calls on life scientists to consider the interactions of life processes with most of the chemical elements in the periodic table. Only in this century have attempts been made to integrate specialty disciplines into a science of bioelements called metallomics. Metallomics forms a fifth group when added to the traditional four building blocks of living cells and their areas of investigations, i.e., sugars (glycomics), fats (lipidomics), proteins (proteomics) and nucleic acids (genomics). Neither an understanding of all the essential metals and their interactions nor the functional impacts of the non-essential metals for life, except established toxic elements such as lead, are widely perceived as important in the basic science communities and in the applied sciences such as medicine and engineering. It is a remarkable oversight that this article attempts to address with representative examples. Full article
(This article belongs to the Special Issue Metals and Metal Complexes in Cell Signaling)
43 pages, 6594 KiB  
Review
Metal Nanozymes: New Horizons in Cellular Homeostasis Regulation
by Hanna Lewandowska, Karolina Wójciuk and Urszula Karczmarczyk
Appl. Sci. 2021, 11(19), 9019; https://doi.org/10.3390/app11199019 - 28 Sep 2021
Cited by 14 | Viewed by 4460
Abstract
Nanomaterials with enzyme-like activity (nanozymes) have found applications in various fields of medicine, industry, and environmental protection. This review discusses the use of nanozymes in the regulation of cellular homeostasis. We also review the latest biomedical applications of nanozymes related to their use [...] Read more.
Nanomaterials with enzyme-like activity (nanozymes) have found applications in various fields of medicine, industry, and environmental protection. This review discusses the use of nanozymes in the regulation of cellular homeostasis. We also review the latest biomedical applications of nanozymes related to their use in cellular redox status modification and detection. We present how nanozymes enable biomedical advances and demonstrate basic design strategies to improve diagnostic and therapeutic efficacy in various diseases. Finally, we discuss the current challenges and future directions for developing nanozymes for applications in the regulation of the redox-dependent cellular processes and detection in the cellular redox state changes. Full article
(This article belongs to the Special Issue Metals and Metal Complexes in Cell Signaling)
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