Novel Inhibitors: Design, Synthesis, Biological Activities and Modelling Studies
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 1095
Special Issue Editors
Interests: medicinal chemistry; HDAC inhibitors; cancer; CNS ligands; total synthesis; method development
Special Issues, Collections and Topics in MDPI journals
Interests: drug design; drug discovery; medicinal chemistry; organic synthesis; lead optimization; anticancer; molecular modeling; in vitro assays
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Altering enzyme activity has profound biological and medicinal effects; thus, enzyme inhibitors enable the selective inhibition of essential pathogenic enzymes (acting as antibiotics, antivirals, or antiparasitic agents) or of aberrant human enzymes (correcting for a pathological condition). Enzyme inhibitors may bind irreversibly (through covalent bonding) or reversibly (through non-covalent bonding), but in either case, drawbacks to the inherent mechanism of action must be considered, adding additional barriers to the development of viable inhibitors. This Special Issue pays homage to the drug discovery progress of inhibitors, which requires exceptional dedication, skill, and creativity.
For this Special Issue, we welcome papers that highlight the development and biological evaluation of organic compounds (this can be addressed from several sub-disciplines, including medicinal chemistry, total synthesis, natural product chemistry, and computational chemistry).
Dr. Hari Krishna Namballa
Dr. Velma Ganga Reddy
Guest Editors
Manuscript Submission Information
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Keywords
- drug design
- medicinal chemistry
- organic synthesis
- total synthesis
- multi-drug resistance
- biological activity
- anticancer
- heterocyclic compounds
- cytotoxicity
- structure–activity relationship
- molecular modeling
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