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Stable Radicals: Synthesis and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 2939

Special Issue Editors


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Guest Editor
CSIC–Instituto de Ciencia de Materiales de Barcelona (ICMAB), Cerdanyola del Valles, Spain
Interests: organic radicals; electron paramagnetic resonance; radical dendrimers; spin-labeled gold nanoparticles; MRI; DNP
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
CSIC–Instituto de Ciencia de Materiales de Barcelona (ICMAB), Cerdanyola del Valles, Spain
Interests: organic radicals; radical dendrimers; spin-labeled gold nanoparticles; electron paramagnetic resonance spectroscopy; magnetic resonance imaging (MRI); dynamic nuclear polarization (DNP); molecular switches
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

More than 120 years have passed since Moses Gomberg discovered the triphenylmethyl radical. Since then, these types of strange open-shell molecules, which are usually thermodynamically and kinetically unstable, have become key to the development of important areas of chemistry and materials science. Throughout all this time, many radicals stable enough to be isolated as pure compounds or crystals have been discovered and characterized via spectroscopic techniques, in particular via magnetic susceptibility measurements, absorption spectroscopy and, above all, electron paramagnetic resonance spectroscopy (EPR).

Today, organic radicals are widely used in areas as diverse as plastics and rubber manufacturing, agriculture or biochemistry. They have applications as building blocks for molecule-based magnets, spintronic devices such as spin transport devices, quantum computers and spin valves, conducting materials and batteries, optoelectronics, etc., and thinking about biomedical applications, bioimaging such as contrast agents for MRI, biosensing, antioxidants or photo-triggered therapies.

In this Special Issue, we would like to reflect on all current trends and applications of organic radicals.

Dr. José Vidal-Gancedo
Dr. Vega Lloveras
Guest Editors

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Keywords

  • organic radicals
  • synthesis
  • EPR
  • spin labels
  • NMR/EPR imaging
  • dynamic nuclear polarization
  • molecular magnetism
  • spintronics

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Published Papers (2 papers)

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Research

16 pages, 2667 KiB  
Article
Efficient Scavenging of TEMPOL Radical by Ascorbic Acid in Solution and Related Prolongation of 13C and 1H Nuclear Spin Relaxation Times of the Solute
by Václav Římal, Eleonora I. Bunyatova and Helena Štěpánková
Molecules 2024, 29(3), 738; https://doi.org/10.3390/molecules29030738 - 5 Feb 2024
Viewed by 1159
Abstract
Dynamic nuclear polarization for nuclear magnetic resonance (NMR) spectroscopy and imaging uses free radicals to strongly enhance the NMR signal of a compound under investigation. At the same time, the radicals shorten significantly its nuclear spin relaxation times which reduces the time window [...] Read more.
Dynamic nuclear polarization for nuclear magnetic resonance (NMR) spectroscopy and imaging uses free radicals to strongly enhance the NMR signal of a compound under investigation. At the same time, the radicals shorten significantly its nuclear spin relaxation times which reduces the time window available for the experiments. Radical scavenging can overcome this drawback. Our work presents a detailed study of the reduction of the TEMPOL radical by ascorbic acid in solution by high-resolution NMR. Carbon-13 and hydrogen-1 nuclear spin relaxations are confirmed to be restored to their values without TEMPOL. Reaction mechanism, kinetics, and the influence of pD and viscosity are thoroughly discussed. The detailed investigation conducted in this work should help with choosing suitable concentrations in the samples for dynamic nuclear polarization and optimizing the measurement protocols. Full article
(This article belongs to the Special Issue Stable Radicals: Synthesis and Applications)
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13 pages, 7003 KiB  
Article
Catalytic System for Cross-Coupling of Heteroaryl Iodides with a Nitronyl Nitroxide Gold Derivative at Room Temperature
by Igor Zayakin, Galina Romanenko, Irina Bagryanskaya, Bogdan Ugrak, Matvey Fedin and Evgeny Tretyakov
Molecules 2023, 28(22), 7661; https://doi.org/10.3390/molecules28227661 - 19 Nov 2023
Cited by 5 | Viewed by 1261
Abstract
A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh3 at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd2(dba)3·CHCl3 and the phosphine ligand MeCgPPh [...] Read more.
A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh3 at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd2(dba)3·CHCl3 and the phosphine ligand MeCgPPh having an adamantane-like framework. The present protocol was found to be well compatible with various heteroaryl iodides, thus opening new horizons in directed synthesis of functionalized nitronyl nitroxides and high-spin molecules. Full article
(This article belongs to the Special Issue Stable Radicals: Synthesis and Applications)
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