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Novel Insights in Some Nanotechnological Formulations and Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2702

Special Issue Editors


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Guest Editor
Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria 21500, Egypt
Interests: microbial resistance; phytotherapy; immunology; nanotoxicology; applied microbiology; nano-composites
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Guest Editor
School of Life Science, Faculty of Science, University of Technology Sydney, NSW 2007, Australia
Interests: chronic respiratory diseases; pharmacology; phytoceuticals; drug delivery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt
Interests: fabrication of nanofiber membrane; biodegradable nanofibers; electrospinning
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The natural sciences and engineering have been completely transformed by nanotechnology. Nanotechnology focuses on the creation and use of nanomaterials or substances with dimensions smaller than 100 nm. Size is the defining characteristic between nanoparticles and other materials; specifically, nanomaterials are defined as having a size of 100 nm in a single dimension, whereas non-nanomaterials are defined as having a size of >100 nm in all dimensions. Nanosensors, nano-sorbents, and fuel cells are just a few examples of the many applications made possible by nanomaterials' superior performance due to their larger surface area to volume ratio. In both gas and liquid phases, nanomaterials have demonstrated an increased adsorption capacity. Nanomaterials' small size, quantum effect, and large surface area provide them with many potential applications. Material selection, doping, and composition can also affect other properties, such as physical, chemical, morphological, mechanical, thermal, optical, magnetic, and conductivity. The unique properties of these nanomaterials have been used in a wide variety of scientific, technological, and engineering disciplines by dedicated scientists and researchers. Energy, medical, environmental research, IT, and food safety are just a few of the key technological industries experiencing and benefiting from the great effect of nanomaterials. Biofunctionalization of some nanoparticles for biomedicine applications proved their powerful presence in relation to in vitro and in vivo analysis protocols that ideally include drug delivery, and several recent astonishing examples of progress. In this Special Issue, we will be devoted to publishing original research and review articles that address these topics and include advances, trends, challenges, and future perspectives regarding synthesizing newly designed nanomaterials and investigating their characteristics as well as enhancing the biological activities and reducing the possible toxicity.

Dr. Bassma H. Elwakil
Dr. Keshav Raj Paudel
Dr. Mohamed Hagar
Guest Editors

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Keywords

  • applied nano
  • applied biosciences
  • nanotoxicology
  • nanofabrication
  • nanostructure characterization
  • nanocomposites
  • nanoemulsions
  • drug delivery
  • water treatment

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Published Papers (1 paper)

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Research

16 pages, 10836 KiB  
Article
Nanoemulsion of Lavandula angustifolia Essential Oil/Gold Nanoparticles: Antibacterial Effect against Multidrug-Resistant Wound-Causing Bacteria
by Balqis A. Fadel, Bassma H. Elwakil, Esraa E. Fawzy, Marwa M. Shaaban and Zakia A. Olama
Molecules 2023, 28(19), 6988; https://doi.org/10.3390/molecules28196988 - 9 Oct 2023
Cited by 5 | Viewed by 2342
Abstract
Hospitalized patients are severely impacted by delayed wound healing. Recently, there has been a growing focus on enhancing wound healing using suitable dressings. Lavandula angustifolia essential oil (LEO) showed potential antibacterial, anti-inflammatory, and wound healing properties. However, the prepared gold nanoparticles possessed multifunctional [...] Read more.
Hospitalized patients are severely impacted by delayed wound healing. Recently, there has been a growing focus on enhancing wound healing using suitable dressings. Lavandula angustifolia essential oil (LEO) showed potential antibacterial, anti-inflammatory, and wound healing properties. However, the prepared gold nanoparticles possessed multifunctional properties. Consequently, the present investigation aimed to synthesize a novel nanosystem consisting of nano-Lavandula angustifolia essential oil and gold nanoparticles prepared through ultrasonic nanoemulsifying techniques in order to promote wound healing and combat bacterial infection. LEO showed potent antibacterial activity against Klebsiella pneumoniae, MRSA and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 32, 16 and 16 µg/mL, respectively, while exhibiting low activity against Proteus mirabilis. Interestingly, the newly formulated nano-gold/nano-Lavandula angustifolia penetrated the preformed P. mirabilis biofilm with a full eradication of the microbial cells, with MIC and MBEC (minimal biofilm eradication concentration) values reaching 8 and 16 µg/mL, respectively. The cytotoxic effect of the novel nanoformula was also assessed against WI-38 fibroblasts vero (normal) cells (IC50 = 0.089 mg/mL) while nano-gold and nano-Lavandula angustifolia showed higher results (IC50 = 0.529, and 0.209 mg/mL, respectively). Nano-gold/nano-Lavandula angustifolia formula possessed a powerful wound healing efficacy with a 96.78% wound closure. These findings revealed that nano-gold/nano-Lavandula angustifolia nanoemulsion can inhibit bacterial growth and accelerate the wound healing rate. Full article
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