Synthetic Small Molecules as Anti-biofilm Agents
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 6743
Special Issue Editors
Interests: synthesis; heterocycles; antibiotic resistance; drug discovery; antitumor activity
Interests: antibiotic resistance; anti-biofilm agents; anti-virulence compounds; anticancer derivatives; sortase A inhibitors
Special Issues, Collections and Topics in MDPI journals
Interests: synthesis; reactivity studies of policondensed nitrogen heterocycles; synthesis of marine-derived analogs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibiotic resistance is a major public health concern, associated with a high social and economic burden. The bacterial ability to form communities, known as biofilms, capable of adhering to abiotic and biotic surfaces is currently considered one of the most important mechanisms of antibiotic resistance, as well as a key virulence factor for many relevant pathogens. Most chronic infections are biofilm-mediated, including pneumonia in cystic fibrosis patients, osteomyelitis, chronic wound infections, and otitis. Additionally, the role of biofilms has recently been recognized both in acute infections and in chronic inflammatory diseases such as Crohn’s disease. Biofilm formation significantly contributes to microbial survival in hostile environments; the bacterial cell was up to 1000 times more resistant within the biofilm with respect to its planktonic form. Contrary to conventional antibiotics, most antibiofilm compounds act as antivirulence agents as they do not affect bacterial growth, imposing a low selective pressure for the onset of antibiotic resistance mechanisms. In the recent decade, many efforts have been made to identify new agents able to interfere with the bacterial biofilm lifecycle, and although many compounds have shown interesting activities for potentially inhibiting biofilm formation or in dispersing preformed biofilms, only a few of these have been validated for their clinical significance using in vivo models. Therefore, much work is still needed in this field.
Prof. Girolamo Cirrincione
Dr. Stella Maria Cascioferro
Dr. Barbara Parrino
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antibiofilm compounds
- antivirulence strategy
- antibiotic resistance
- persister cells
- ESKAPE pathogens
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
