New Generation of Microtubule-Interacting Anticancer Agents
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (20 April 2016) | Viewed by 20538
Special Issue Editor
Interests: drug discovery; anticancer agents; antimicrobial agents; anti-inflammatory agents; enzyme inhibitors; computer-aided drug design; structure-based drug design
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Microtubule-interacting anticancer drugs, such as taxanes and vinca alkaloids, have demonstrated their significant efficacy in cancer chemotherapy. These drugs alter microtubule dynamics and act as cell mitosis inhibitors. These drugs block cell cycle progression in cancer cells and initiate apoptosis to inhibit their aggressive growth, leading to eradication of tumor. However, inherent and acquired drug-resistance is a serious issue for these drugs. A number of new-generation compounds of these classes and others have been showing activities and efficacies against various drug-resistant cancer cell lines and tumor xenografts. Thus, exploration of new microtubule-interacting anticancer agents is a highly promising approach to discover and develop efficacious chemotherapeutic options for the management of cancer. Highly potent microtubule-interacting anticancer agents are useful as cytotoxic “warheads” for tumor-targeted drug delivery in the form of antibody-drug conjugates (ADCs), small-molecule drug conjugates (SMDCs), nanocarrier-drugs, etc. Activities against cancer stem cells are also newer and important aspect in anticancer drug discovery to prevent metastasis and recurrence. In addition, the possible discovery or identification of new mechanism(s) of action for microtubule-interacting agents is very important for drug development. In this Special Issue of Molecules, titled "New Generation of Microtubule-Interacting Anticancer Agents", we invite manuscript submissions that address the subjects mentioned above. Original research articles or Reviews that describe the combination of new drug design or identification, medicinal chemistry and biology are especially welcome.
Prof. Dr. Iwao Ojima
Guest Editor
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Keywords
- mechanism of action
- drug-resistance and solutions
- taxanes and taxoids
- vinca alkaloids
- cryptophycins
- discodermolide
- laulimalide
- epothilones
- binding pose identification
- computer-aided drug design
- fragment-based drug design
- tumor-targeted drug delivery
- drug combinations
- drug discovery
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