Antitumor and Antiviral Potentials of Natural Products and Their Synthetic Analogs
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 6457
Special Issue Editor
2. Adjunct Associate Professor, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hil, NC, USA
Interests: medicinal chemistry; drug discovery; natural products; antitumor; anti-virus; synthesis of bioactive compounds; chemical biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer is the second leading cause of death worldwide, and almost 9.6 million people died from cancer in 2018. On the other hand, infectious diseases caused by viruses, fungi, bacteria, or protozoa, are the top cause of death in developing countries. In recent years, new viruses and pathogenic microorganisms have emerged causing cases of serious illness, called emerging infectious disease (EID). Among EIDs caused by viruses, AIDS has been known as a major global public health issue, and 38 million people in the world were living with HIV in 2019. Most recently, the pandemic of COVID-19 by SARS-CoV-2 has been another severe global issue. Besides, some viruses, such as hepatitis and human papillomavirus (HPV), are also known to be responsible for cancer cases. Therefore, drug discovery and development to overcome cancer and viruses is an urgent task for scientists in related fields.
Natural products have contributed significantly to drug discovery. Especially in the area of cancer, many of the mainstream of anticancer drugs came from natural products and their derivatives. One-third of antiviral drugs have also been discovered based on natural products.
This Special Issue will collect original research and review articles focusing on notable and recent contributions in the discovery and development of novel anticancer/antiviral drug candidates from the natural source. Their updated knowledge from the various research fields is welcome. This could be of great interest for multiple categories of scientists managing in the different research area, such as natural product chemistry including isolation and structural elucidation, phytochemistry, synthetic, and medicinal chemistry, including modified natural compounds with improved biological activity, pharmacology, chemical biology, molecular biology, and mechanisms of action study using natural products or their related compounds, and so on. The biological study of natural extracts without an appropriate chemical characterization will not be considered.
Prof. Dr. Kyoko Nakagawa-Goto
Guest Editor
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Keywords
- natural products
- natural product derivatives
- synthetic derivatives inspired by natural scaffolds
- total synthesis
- phytochemistry
- isolation and structural elucidation
- drug discovery and development
- antitumor/antiproliferative activity
- chemosensitizer
- cancer prevention
- structure–activity relationship
- mechanisms of action study
- Chemical biology
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