molecules-logo

Journal Browser

Journal Browser

Homogeneous and Heterogeneous Catalysis for the Synthesis of Fine Chemicals

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (14 August 2023) | Viewed by 3557

Special Issue Editor


E-Mail Website
Guest Editor
School of Molecular Science & Engineering, Vidyasirimedhi Institute of Science and Technology, Rayong, Thailand
Interests: catalysis(homogeneous and heterogeneous); CO2 conversion; cyclic carbonate synthesis

Special Issue Information

Dear Colleagues,

Catalysis is a crucial process in every aspect of chemistry, ranging from established industrial processes to drug discovery and synthesis, and to vital biochemical cycles. The design of new compounds and materials, either metal-based or metal-free (organocatalysis) is, naturally, at the heart of catalysis science. In this context, heterogeneous catalysts have an edge over their homogeneous counterparts for the sake of product purification and recyclability; however, molecular catalysis is crucial to the understanding of reaction mechanisms because it facilitates reaction monitoring via readily available techniques. However, many catalytic processes, often including those that are already industrially applied, still suffer from poor yields, selectivities, tedious separation procedures, etc., and necessitate new ideas and approaches. Therefore, this Special Issue of Molecules is dedicated to new cutting-edge strategies to push the boundaries of catalysis toward the preparation of fine chemicals by either homogeneous or heterogeneous catalysis. This can be achieved either through the design of new catalysts and materials, the reinvention of the catalytic methodology, or both. In all cases, particular attention should be directed to the investigation of the reaction mechanism, especially for new catalysts and reactions.

Dr. Valerio D' Elia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • design of new catalysts and materials
  • reinvention of the catalytic methodology
  • fine chemicals
  • homogeneous and heterogeneous catalysis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 2651 KiB  
Article
Improved Process for the Synthesis of 3-(3-Trifluoromethylphenyl)propanal for More Sustainable Production of Cinacalcet HCl
by Vikas Damu Rathod, Stefano Paganelli, Marijan Kočevar, Marko Krivec and Oreste Piccolo
Molecules 2023, 28(16), 6042; https://doi.org/10.3390/molecules28166042 - 13 Aug 2023
Viewed by 1538
Abstract
Cinacalcet (I), sold as hydrochloride salt, is a calcimimetic drug which has been approved for the treatment of secondary hyperparathyroidism in patients with chronic renal disease and for the treatment of hypercalcemia in patients with parathyroid carcinoma. Here, an improved method [...] Read more.
Cinacalcet (I), sold as hydrochloride salt, is a calcimimetic drug which has been approved for the treatment of secondary hyperparathyroidism in patients with chronic renal disease and for the treatment of hypercalcemia in patients with parathyroid carcinoma. Here, an improved method for the synthesis of 3-(3-trifluoromethylphenyl)propanal (II), a key intermediate for the preparation of I, is described. The protocol required a Mizoroki–Heck cross-coupling reaction between 1-bromo-3-(trifluoromethyl)benzene and acroleine diethyl acetal, catalyzed by Pd(OAc)2 in the presence of nBu4NOAc (tetrabutylammonium acetate), followed by the hydrogenation reaction of the crude mixture of products in a cascade process. Palladium species, at the end of the reaction, were efficiently recovered as Pd/Al2O3. The procedure was developed under conventional heating conditions as well as under microwave-assisted conditions. The obtained mixture of 1-(3,3-diethoxypropyl)-3-(trifluoromethyl)benzene (III), impure for ethyl 3-(3-trifluoromethylphenyl) propanoate (IV), was finally treated, under mild conditions, with potassium diisobutyl-tert-butoxyaluminum hydride (PDBBA) to obtain after hydrolysis 3-(3-trifluoromethylphenyl)propanal (II), in an excellent overall yield and very high purity. Microwave conditions permitted a reduction in reaction times without affecting selectivity and yield. The final API was obtained through reductive amination of (II) with (R)-(+)-1-(1-naphthyl)ethylamine (V) using a catalyst prepared by us with a very low content of precious metal. Full article
Show Figures

Figure 1

Review

Jump to: Research

25 pages, 10994 KiB  
Review
Recent Developments in Direct C–H Functionalization of Quinoxalin-2(1H)-Ones via Heterogeneous Catalysis Reactions
by Qiming Yang, Hu Wang, Xiang Wang and Yizhu Lei
Molecules 2023, 28(13), 5030; https://doi.org/10.3390/molecules28135030 - 27 Jun 2023
Cited by 6 | Viewed by 1733
Abstract
In recent years, Web of Science has published nearly one hundred reports per year on quinoxalin-2(1H)-ones, which have attracted great interest due to their wide applications in pharmaceutical and materials fields, especially in recyclable heterogeneous catalytic reactions for direct C–H functionalisation. [...] Read more.
In recent years, Web of Science has published nearly one hundred reports per year on quinoxalin-2(1H)-ones, which have attracted great interest due to their wide applications in pharmaceutical and materials fields, especially in recyclable heterogeneous catalytic reactions for direct C–H functionalisation. This review summarises for the first time the methods and reaction mechanisms of heterogeneous catalytic reactions of quinoxalin-2(1H)-ones, including six major types of heterogeneous catalysts involved. The heterogeneous reactions of quinoxalin-2(1H)-ones are summarised by classifying different types of catalytic materials (graphitic phase carbon nitride, MOF, COF, ion exchange resin, piezoelectric materials, and microsphere catalysis). In addition, this review discusses the future development of heterogeneous catalytic reactions of quinoxalin-2(1H)-ones, including the construction of C-B/Si/P/RF/X/Se bonds by heterogeneous catalytic reactions, the enrichment of heterogeneous catalysts such as metal oxides, graphene-based composites, doped metal nanoparticles, and molecular sieve-based porous materials, asymmetric synthesis, and other areas. The aim of this review is to contribute to the development of green and sustainable heterogeneous reaction methods for quinoxalin-2(1H)-ones with applications in materials chemistry and pharmacology. Full article
Show Figures

Scheme 1

Back to TopTop