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Biopolymer Based Solutions for Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2363

Special Issue Editor


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Guest Editor
Centro de Investigação de Montanha, Instituto Politecnico de Braganca, Braganca, Portugal
Interests: polyurethane chemistry; polyurethane dispersions; green chemistry; bio-based materials; renewable entities and additives; composite materials; polymers with tailored properties
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Special Issue Information

Dear Colleagues,

The innovative solutions in the biomedical area implies the development of new materials with an increasingly trend to enclose specific characteristics, including renewability and sustainability. Among others, the use of biopolymers to design new products is presented as an attractive strategy; their green character, together with their biocompatibility, non-toxicity, and potential to carry bioactive compounds, positioned biopolymers as one of the most promising alternatives for the preparation of new biomedical formulations. Additionally, their versatility facilitates their processing, resulting in diverse forms according to their application, from scaffolds to coatings and wounds. Note also that the addition of bioactive compounds, drugs, growth factors, or cells enable the design of tailor-made formulations to improve fortification, curation, or regeneration processes in which usually these types of systems are used.

In this context, this Special Issue pretends to englobe an overview about the actual and most promising trends in the biomedical area, including the synthesis and modification of biopolymers, the addition of bioactive and biologic entities, their processing methods, and the applicability of the developed biomaterials.

Dr. Arantzazu Santamaria-Echart
Guest Editor

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Keywords

  • biopolymers
  • sustainable preparation strategies
  • materials with tailored properties
  • advanced processing technologies
  • biomedical applications
  • scaffolds
  • drug delivery

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Published Papers (1 paper)

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Research

19 pages, 7792 KiB  
Article
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects
by Carlos Humberto Valencia-Llano, Diego López-Tenorio, Marcela Saavedra, Paula A. Zapata and Carlos David Grande-Tovar
Molecules 2022, 27(18), 5745; https://doi.org/10.3390/molecules27185745 - 6 Sep 2022
Cited by 9 | Viewed by 2036
Abstract
Autologous bone is the gold standard in regeneration processes. However, there is an endless search for alternative materials in bone regeneration. Xenografts can act as bone substitutes given the difficulty of obtaining bone tissue from patients and before the limitations in the availability [...] Read more.
Autologous bone is the gold standard in regeneration processes. However, there is an endless search for alternative materials in bone regeneration. Xenografts can act as bone substitutes given the difficulty of obtaining bone tissue from patients and before the limitations in the availability of homologous tissue donors. Bone neoformation was studied in critical-size defects created in the parietal bone of 40 adult male Wistar rats, implanted with xenografts composed of particulate bovine hydroxyapatite (HA) and with blocks of bovine hydroxyapatite (HA) and Collagen, which introduces crystallinity to the materials. The Fourier-transform infrared spectroscopy (FTIR) analysis demonstrated the carbonate and phosphate groups of the hydroxyapatite and the amide groups of the collagen structure, while the thermal transitions for HA and HA/collagen composites established mainly dehydration endothermal processes, which increased (from 79 °C to 83 °C) for F2 due to the collagen presence. The xenograft’s X-ray powder diffraction (XRD) analysis also revealed the bovine HA crystalline structure, with a prominent peak centered at 32°. We observed macroporosity and mesoporosity in the xenografts from the morphology studies with heterogeneous distribution. The two xenografts induced neoformation in defects of critical size. Histological, histochemical, and scanning electron microscopy (SEM) analyses were performed 30, 60, and 90 days after implantation. The empty defects showed signs of neoformation lower than 30% in the three periods, while the defects implanted with the material showed partial regeneration. InterOss Collagen material temporarily induced osteon formation during the healing process. The results presented here are promising for bone regeneration, demonstrating a beneficial impact in the biomedical field. Full article
(This article belongs to the Special Issue Biopolymer Based Solutions for Biomedical Applications)
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